Long-term effects of cerebellar anodal transcranial direct current stimulation (tDCS) on the acquisition and extinction of conditioned eyeblink responses.
Long-term effects of cerebellar anodal transcranial direct current stimulation (tDCS) on the acquisition and extinction of conditioned eyeblink responses.
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DOI：
10.1038/s41598-020-80023-8
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发表时间：
2020-12-31
影响因子：
4.6
通讯作者：
Gerwig M
中科院分区：
文献类型：
--
作者：
Kimpel O;Hulst T;Batsikadze G;Ernst TM;Nitsche MA;Timmann D;Gerwig M
据报道，小脑经颅直流电刺激（tDCS）可以增强条件眨眼反应（CR）的习得，这是联想运动学习的一种形式。本研究的目的是确定小脑tDCS对cr的获得和消失可能的长期影响。在40名年轻健康的人类参与者中进行延迟眨眼条件反射。在第1天，进行了100组CS（条件刺激）-US（非条件刺激）配对试验。在前50个配对的CS-US试验中，20名参与者接受了小脑阳极tDCS， 20名参与者接受了假刺激。在第2、8和29天进行50次配对CS-US试验，第29天进行30次纯cs消光试验。正假两组间CR的获得无显著性差异。在消失期间，与假手术组相比，阳极组的CR发生率显著降低，表明保留减少。在阳极组，学习相关的CR幅度增加有降低的趋势，CR时间有延迟的趋势。目前的数据不能证实先前的发现，即阳极小脑tDCS诱导的CRs获取增强。相反，目前的研究结果表明，阳极小脑tDCS对CR保留和可能的CR性能有不利影响。
Cerebellar transcranial direct current stimulation (tDCS) has been reported to enhance the acquisition of conditioned eyeblink responses (CR), a form of associative motor learning. The aim of the present study was to determine possible long-term effects of cerebellar tDCS on the acquisition and extinction of CRs. Delay eyeblink conditioning was performed in 40 young and healthy human participants. On day 1, 100 paired CS (conditioned stimulus)–US (unconditioned stimulus) trials were applied. During the first 50 paired CS–US trials, 20 participants received anodal cerebellar tDCS, and 20 participants received sham stimulation. On days 2, 8 and 29, 50 paired CS–US trials were applied, followed by 30 CS-only extinction trials on day 29. CR acquisition was not significantly different between anodal and sham groups. During extinction, CR incidences were significantly reduced in the anodal group compared to sham, indicating reduced retention. In the anodal group, learning related increase of CR magnitude tended to be reduced, and timing of CRs tended to be delayed. The present data do not confirm previous findings of enhanced acquisition of CRs induced by anodal cerebellar tDCS. Rather, the present findings suggest a detrimental effect of anodal cerebellar tDCS on CR retention and possibly CR performance.
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DOI：
10.1523/jneurosci.2184-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Galea JM;Jayaram G;Ajagbe L;Celnik P
通讯作者：
Celnik P
影响因子：
4.2
作者：
Hardwick RM;Celnik PA
通讯作者：
Celnik PA
影响因子：
7.8
作者：
Hesslow, Germund;Jirenhed, Dan-Anders;Johansson, Fredrik
通讯作者：
Johansson, Fredrik
影响因子：
1.7
作者：
HESSLOW, G;IVARSSON, M
通讯作者：
IVARSSON, M
影响因子：
5.5
作者：
Cheeran, Binith;Talelli, Penelope;Rothwell, John C.
通讯作者：
Rothwell, John C.