Development and organization of the zebrafish intestinal epithelial stem cell niche.
Development and organization of the zebrafish intestinal epithelial stem cell niche.
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DOI：
10.1002/dvdy.16
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Wallace KN
中科院分区：
文献类型：
--
作者：
Li J;Prochaska M;Maney L;Wallace KN
脊椎动物肠上皮干细胞生态位的发育始于胚胎发生，但成熟发生在胚胎后。哺乳动物肠隐窝中含有干细胞，其中散布着调节增殖的分泌细胞。上皮细胞被指定为分泌细胞或肠细胞，因为它们在哺乳动物的绒毛上迁移或在斑马鱼中折叠。斑马鱼在胚胎发生结束时形成了一个功能肠，但还需要4周的时间才能发育成成人的增殖模式。我们描述了胚胎后期肠上皮干细胞生态位的发育。在胚胎发生后的前2周，不同的上皮细胞群依次经历一个或两个细胞周期，似乎变得静止，并保持在折叠基部。第三周开始不对称分裂，增殖的后代向上移动。直到第四周结束时，才在褶皱尖端观察到凋亡细胞。分泌细胞穿插于褶间基增殖细胞之间，在第3周和第4周数量增加，同时增殖模式发生变化。斑马鱼胚胎后肠上皮的发育包括2周的缓慢增殖，随后2周的蜕变为成体结构。
Development of the vertebrate intestinal epithelial stem cell niche begins during embryogenesis but maturation occurs postembryonic. The intestinal mammalian crypt contains stem cells interspersed by secretory cells that play a role in regulation of proliferation. Epithelial cells are specified as either secretory or enterocytes as they migrate up the villi in mammals or fold in zebrafish. Zebrafish forms a functional intestine by the end of embryogenesis but takes another 4 weeks to develop the adult proliferation pattern. We characterize development of the intestinal epithelial stem cell niche during the postembryonic period. During the first 2-weeks postembryogenesis, different groups of epithelial cells sequentially proceed through one or two cell cycles, appear to become quiescent, and remain at the interfold base. The third week begins asymmetric divisions with proliferative progeny moving up the folds. Apoptotic cells are not observed at the fold tip until the end of the fourth week. Secretory cells intersperse among interfold base proliferative cells, increasing in number during the third and fourth weeks with a coincident change in proliferation pattern. Zebrafish postembryonic intestinal epithelial development consists of 2 weeks of slow proliferation followed by 2 weeks of metamorphosis to the adult structure.
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DOI：
10.1002/dvdy.22540
发表时间：
2011-03
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Spence JR;Lauf R;Shroyer NF
通讯作者：
Shroyer NF
影响因子：
7.7
作者：
Haramis, APG;Hurlstone, A;Clevers, HC
通讯作者：
Clevers, HC
影响因子：
3.7
作者：
Tan, Chin Wee;Hirokawa, Yumiko;Burgess, Antony W.
通讯作者：
Burgess, Antony W.
DOI：
10.1007/bf02932850
发表时间：
1982-01-01
期刊：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY
影响因子：
--
作者：
ALNAFUSSI, AI;WRIGHT, NA
通讯作者：
WRIGHT, NA
影响因子：
9.8
作者：
Langlands, Alistair J.;Almet, Axel A.;Nathke, Inke S.
通讯作者：
Nathke, Inke S.