Circadian thermosensitive characteristics of suprachiasmatic neurons in vitro.

Circadian thermosensitive characteristics of suprachiasmatic neurons in vitro.
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体外视交叉上神经元的昼夜温敏特性。

DOI:
10.1152/ajpregu.1994.266.6.r1876
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发表时间:
1994
期刊:
The American journal of physiology
影响因子:
--
通讯作者:
Boulant,JA
Boulant,JA
中科院分区:
--
文献类型:
--
作者:
Derambure,PS;Boulant,JA

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下丘脑视交叉上核(SCN)中的昼夜节律起搏器影响包括体温在内的多个调节系统。为了研究SCN神经元放电频率和温度敏感性的昼夜变化,在组织温度变化期间记录大鼠下丘脑额叶脑片背内侧和腹外侧SCN的单单位活动。当根据昼夜节律时间(CT)进行分析时,305个神经元的特征在于放电率和208个神经元的特征在于温度敏感性。昼夜节律放电率的变化是明显的,只有在背内侧SCN,峰值放电率发生在主观的一天。SCN神经元温度敏感性的昼夜变化也被观察到,但最大的温度敏感性发生在主观夜间。温度敏感性的增加在腹外侧SCN中最为显著,在CT 16- 20-h期间,其中> 40%的神经元是温敏感的。神经元温度敏感性的这些变化可能反映了体温和昼夜节律之间的相互作用。
The circadian pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) affects several regulatory systems, including body temperature. To study circadian changes in the firing rate and thermosensitivity of SCN neurons, single-unit activity was recorded from the dorsomedial and ventrolateral SCN in frontal slices of rat hypothalamus during changes in tissue temperature. When analyzed according to circadian time (CT), 305 neurons were characterized by firing rate and 208 neurons were characterized by thermosensitivity. Circadian firing-rate changes were evident only in the dorsomedial SCN, with peak firing rates occurring during the subjective day. Circadian changes in SCN neuronal thermosensitivity also were observed, but the greatest thermosensitivity occurred during the subjective night. Increased thermosensitivity was most dramatic in the ventrolateral SCN, where > 40% of the neurons were warm sensitive in the CT 16- to 20-h period. These changes in neuronal thermosensitivity may reflect interactions between body temperature and circadian rhythms.
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