Targeting the perpetrator: breast cancer stem cell therapeutics.

Targeting the perpetrator: breast cancer stem cell therapeutics.
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DOI:
10.2174/138945010792006843
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发表时间:
2010-09
影响因子:
3.2
通讯作者:
Behbod F
Behbod F
中科院分区:
医学4区
文献类型:
--
作者:
Pal A;Valdez KE;Carletti MZ;Behbod F

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肿瘤可能起源于罕见的癌症干细胞(CSC)群体的假设近年来获得了极大的普及,并得到了一些开创性工作的广泛支持。靶向CSC的癌症疗法对于癌症患者的无复发存活具有无限的潜力。因此,管理CSC的生物学途径的知识是非常重要的,这篇综述的重点是CSC的生物学和靶向治疗方法的最新进展。
The hypothesis that tumors may originate from a rare population of cancer stem cells (CSCs) has gained tremendous popularity in recent years and is supported extensively by several pioneering works. Cancer therapies targeting CSCs have unlimited potential for relapse free survival of cancer patients. As a result, knowledge of biological pathways that govern CSCs is very important and this review is focused on the biology of CSCs and recent advances in therapeutic approaches targeting them.
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