Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.
Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.
复制标题
异突触可塑性和发展中神经元回路的经验依赖的改进。
DOI：
10.3389/fncir.2021.803401
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发表时间：
2021
影响因子：
3.5
通讯作者：
Sur M
中科院分区：
文献类型：
--
作者：
Jenks KR;Tsimring K;Ip JPK;Zepeda JC;Sur M
神经元在发育的关键时期重塑其突触的结构和强度，以优化感知和认知。许多这些发育性突触变化被认为是通过经验依赖性可塑性的突触特异性同源突触形式发生的。然而，同突触可塑性也可以通过异突触相互作用诱导或促进相邻突触的可塑性。几十年的体外研究已经揭示了许多异突触可塑性的分子机制，这些机制介导了同突触可塑性的局部补偿，促进了附近突触的进一步可塑性发作，以及相邻突触协同作用对可塑性的协同诱导。这些发现极大地受益于新的工具和技术，这些工具和技术允许单个突触成像和操纵活神经元的结构，功能和蛋白质动力学。随着最近体内研究类似工具的出现和应用，现在可以探索异突触可塑性如何对关键时期和神经元回路的发育做出贡献。在这篇综述中，我们将首先定义异突触可塑性的形式，并描述我们目前对其分子机制的理解。然后，我们将概述异突触可塑性如何可能导致有意义的细化神经元的反应和观察，表明这种机制确实在体内工作。最后，我们将使用一个良好的研究模型的皮质可塑性眼优势可塑性在视觉皮层发育的关键时期，突出异突触和发育形式的可塑性之间的分子重叠，并提出未来研究的潜在途径。
Neurons remodel the structure and strength of their synapses during critical periods of development in order to optimize both perception and cognition. Many of these developmental synaptic changes are thought to occur through synapse-specific homosynaptic forms of experience-dependent plasticity. However, homosynaptic plasticity can also induce or contribute to the plasticity of neighboring synapses through heterosynaptic interactions. Decades of research in vitro have uncovered many of the molecular mechanisms of heterosynaptic plasticity that mediate local compensation for homosynaptic plasticity, facilitation of further bouts of plasticity in nearby synapses, and cooperative induction of plasticity by neighboring synapses acting in concert. These discoveries greatly benefited from new tools and technologies that permitted single synapse imaging and manipulation of structure, function, and protein dynamics in living neurons. With the recent advent and application of similar tools for in vivo research, it is now feasible to explore how heterosynaptic plasticity contribute to critical periods and the development of neuronal circuits. In this review, we will first define the forms heterosynaptic plasticity can take and describe our current understanding of their molecular mechanisms. Then, we will outline how heterosynaptic plasticity may lead to meaningful refinement of neuronal responses and observations that suggest such mechanisms are indeed at work in vivo. Finally, we will use a well-studied model of cortical plasticity—ocular dominance plasticity during a critical period of visual cortex development—to highlight the molecular overlap between heterosynaptic and developmental forms of plasticity, and suggest potential avenues of future research.
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影响因子：
16.2
作者：
Chowdhury, Shoaib;Shepherd, Jason D.;Worley, Paul F.
通讯作者：
Worley, Paul F.
影响因子：
6.2
作者：
Benediktsson, Adrienne M.;Marrs, Glen S.;Tu, Jian Cheng;Worley, Paul F.;Roth-Stein, Jeffrey D.;Bergles, Dwight E.;Dailey, Michael E.
通讯作者：
Dailey, Michael E.
DOI：
10.1073/pnas.0609596104
发表时间：
2007-01-23
影响因子：
11.1
作者：
Crozier, Robert A.;Wang, Yun;Bear, Mark F.
通讯作者：
Bear, Mark F.
DOI：
10.1073/pnas.90.16.7661
发表时间：
1993-08-15
影响因子：
11.1
作者：
CALLAWAY, EM;KATZ, LC
通讯作者：
KATZ, LC
DOI：
10.1073/pnas.86.20.8113
发表时间：
1989-10-01
影响因子：
11.1
作者：
BONHOEFFER, T;STAIGER, V;AERTSEN, A
通讯作者：
AERTSEN, A