Clinical Manifestations and Epigenetic Regulation of Oral Herpesvirus Infections.
Clinical Manifestations and Epigenetic Regulation of Oral Herpesvirus Infections.
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口腔疱疹病毒感染的临床表现和表观遗传学调控。
DOI：
10.3390/v13040681
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发表时间：
2021-04-15
期刊：
影响因子：
--
通讯作者：
Toth Z
中科院分区：
文献类型：
--
作者：
Atyeo N;Rodriguez MD;Papp B;Toth Z
口腔通常是病毒与人体相互作用的第一个部位。口腔上皮是病毒进入、复制和传播到其他细胞类型的主要场所，在那里可以建立慢性感染。此外，唾液已被证明是许多病毒人际传播的主要途径。从临床角度来看，病毒感染可导致几种口腔表现，从常见的口内病变到肿瘤。尽管最初的口腔感染的临床和生物学相关性，很少有人知道口腔中的病毒生命周期的调节机制。一些病毒利用宿主的表观遗传机制来促进它们自己的生命周期。重要的是，宿主染色质修饰酶的病毒劫持也可导致宿主因子的失调，并且在致癌病毒的情况下，可能最终在促进肿瘤发生中发挥作用。鉴于已知的表观遗传调节病毒感染的作用，表观遗传靶向抗病毒治疗最近已被探索作为慢性病毒感染的治疗选择。在这篇综述中，我们强调了三种疱疹病毒在口腔感染中的作用，包括单纯疱疹病毒1型，爱泼斯坦-巴尔病毒和卡波西肉瘤相关疱疹病毒。我们专注于这些病毒各自的口腔临床表现及其表观遗传调控，特别强调口腔上皮中的病毒生命周期。
The oral cavity is often the first site where viruses interact with the human body. The oral epithelium is a major site of viral entry, replication and spread to other cell types, where chronic infection can be established. In addition, saliva has been shown as a primary route of person-to-person transmission for many viruses. From a clinical perspective, viral infection can lead to several oral manifestations, ranging from common intraoral lesions to tumors. Despite the clinical and biological relevance of initial oral infection, little is known about the mechanism of regulation of the viral life cycle in the oral cavity. Several viruses utilize host epigenetic machinery to promote their own life cycle. Importantly, viral hijacking of host chromatin-modifying enzymes can also lead to the dysregulation of host factors and in the case of oncogenic viruses may ultimately play a role in promoting tumorigenesis. Given the known roles of epigenetic regulation of viral infection, epigenetic-targeted antiviral therapy has been recently explored as a therapeutic option for chronic viral infection. In this review, we highlight three herpesviruses with known roles in oral infection, including herpes simplex virus type 1, Epstein–Barr virus and Kaposi’s sarcoma-associated herpesvirus. We focus on the respective oral clinical manifestations of these viruses and their epigenetic regulation, with a specific emphasis on the viral life cycle in the oral epithelium.
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影响因子：
6
作者：
Batie M;Druker J;D'Ignazio L;Rocha S
通讯作者：
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影响因子：
30.3
作者：
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Lieberman PM
影响因子：
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作者：
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Zimmermann, Holger
影响因子：
5.4
作者：
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通讯作者：
Kung, Hsing-Jien
DOI：
10.1038/nrm1005
发表时间：
2003-01
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Bomsel M;Alfsen A
通讯作者：
Alfsen A