Variable effects of underlying diseases on the prognosis of patients with COVID-19.
Variable effects of underlying diseases on the prognosis of patients with COVID-19.
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DOI：
10.1371/journal.pone.0254258
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Park HJ
中科院分区：
文献类型：
--
作者：
Choi YJ;Park JY;Lee HS;Suh J;Song JY;Byun MK;Cho JH;Kim HJ;Park HJ
基础疾病可能是冠状病毒病（COVID-19）患者预后不良的危险因素;但我们仍然不知道这些疾病是否是影响预后的独立因素，哪些类型的基础疾病是危险因素，以及哪些类型的临床结局受到影响。我们回顾性分析了截至2020年5月15日，7，590名使用严重急性呼吸综合征-冠状病毒-2 RNA聚合酶链反应检测诊断的COVID-19去识别患者的队列数据。我们使用了韩国健康保险审查和评估服务提供的链接医疗索赔数据。使用2019年1月1日至2019年12月31日患者档案中的诊断代码识别基础疾病。COVID-19患者的总死亡率为3. 0%。在调整了年龄、性别和伴随的慢性疾病后，我们发现充血性心力衰竭、慢性肺部疾病、无慢性并发症的糖尿病、肾脏疾病和恶性肿瘤是显著增加治疗费用的因素。脑血管疾病、慢性肺部疾病、瘫痪是延长住院时间的独立因素。糖尿病伴慢性并发症与重症监护室入院独立相关。另外，潜在的充血性心力衰竭（比值比[OR]，1.724; P = 0.003），痴呆（OR，1.598; P = 0.012），糖尿病伴和不伴慢性并发症（OR分别为1.821; P = 0.002和1.518; P = 0.022）、肾脏疾病（OR为2.299; P = 0.002）和恶性肿瘤（OR为1.529; P = 0.039）是与死亡相关的重要因素，即使在调整后也是如此。基础疾病是COVID-19患者预后不良的重要独立因素。根据基础疾病和临床结局的类型，影响是可变的。因此，应更密切地监测患有基础疾病的COVID-19患者，因为他们预后不良的风险更大。
Underlying diseases might be risk factors for poor prognosis in patients with coronavirus disease (COVID-19); however, we still do not know whether these diseases are independent factors affecting prognosis, which type of underlying diseases are risk factors, and which type of clinical outcomes are affected. We retrospectively reviewed cohort data from 7,590 de-identified patients with COVID-19 who were diagnosed using severe acute respiratory syndrome-coronavirus-2 RNA polymerase chain reaction test up to May 15, 2020. We used linked-medical claims data provided by the Health Insurance Review and Assessment Service in South Korea. Underlying diseases were identified using the diagnostic codes in the patients’ files from January 1, 2019 to December 31, 2019. The total mortality rate was 3.0% in patients with COVID-19. After adjusting for age, sex, and concomitant chronic conditions, we found that congestive heart failure, chronic pulmonary diseases, diabetes without chronic complications, renal diseases, and malignancy were factors that significantly increased the cost of treatment. Cerebrovascular disease, chronic pulmonary disease, and paralysis were found to be independent factors significant in prolonging hospital stay. Diabetes with chronic complications was independently associated with intensive care unit admission. In addition, underlying congestive heart failure (odds ratio [OR], 1.724; P = 0.003), dementia (OR, 1.598; P = 0.012), diabetes with and without chronic complications (OR, 1.821; P = 0.002 and OR, 1.518; P = 0.022, respectively), renal disease (OR, 2.299; P = 0.002), and malignancy (OR, 1.529; P = 0.039) were significant factors associated with death, even after adjustments. Underlying diseases were significant independent factors of the poor prognosis in patients with COVID-19. The effects were variable according to the type of underlying disease and clinical outcome. Therefore, patients with COVID-19 with underlying diseases should be monitored more closely because they are more at risk of a poor prognosis.
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影响因子：
6.1
作者：
Liu, Kui;Fang, Yuan-Yuan;Liu, Hui-Guo
通讯作者：
Liu, Hui-Guo
DOI：
10.1152/ajpendo.00124.2020
发表时间：
2020-05-01
影响因子：
5.1
作者：
Muniyappa, Ranganath;Gubbi, Sriram
通讯作者：
Gubbi, Sriram
DOI：
10.26355/eurrev_201808_15635
发表时间：
2018-08-01
影响因子：
3.3
作者：
Nassar, M. S.;Bakhrebah, M. A.;Zaher, W. A.
通讯作者：
Zaher, W. A.
影响因子：
168.9
作者：
Niebauer, J;Volk, HD;Anker, SD
通讯作者：
Anker, SD
DOI：
10.1016/0021-9681(87)90171-8
发表时间：
1987-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
CHARLSON, ME;POMPEI, P;MACKENZIE, CR
通讯作者：
MACKENZIE, CR