Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis.
Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis.
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DOI：
10.1038/srep00332
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发表时间：
2012
影响因子：
4.6
通讯作者：
Ooshima, Takashi
中科院分区：
文献类型：
--
作者：
Kojima, Ayuchi;Nakano, Kazuhiko;Wada, Koichiro;Takahashi, Hirokazu;Katayama, Kazufumi;Yoneda, Masato;Higurashi, Takuma;Nomura, Ryota;Hokamura, Kazuya;Muranaka, Yoshinori;Matsuhashi, Nobuyuki;Umemura, Kazuo;Kamisaki, Yoshinori;Nakajima, Atsushi;Ooshima, Takashi
虽然口腔细菌相关的全身性疾病已有报道，但龋病的病原体变形链球菌与溃疡性结肠炎(UC)之间的联系尚未见报道。我们研究了不同变形链球菌对葡聚糖硫酸钠(DSS)诱导的小鼠结肠炎的影响。使用变形链球菌的特异性菌株TW295可引起结肠炎的加重；标准菌株MT8148不会。观察TW295在肝细胞中的定位。肝脏中干扰素-γ的表达也增加，表明肝脏是变形链球菌介导的结肠炎加重的靶器官。UC患者特异性菌株的检出频率明显高于正常对照组。服用从患者身上分离的特定变形链球菌会导致结肠炎的加重。感染高毒力的特定类型变形链球菌可能是UC加重的潜在危险因素。
Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans, caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans-mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.
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影响因子：
3
作者：
Nomura, Ryota;Nakano, Kazuhiko;Ooshima, Takashi
通讯作者：
Ooshima, Takashi
影响因子：
4.9
作者：
Saubermann, LJ;Nakajima, A;Blumberg, RS
通讯作者：
Blumberg, RS
影响因子：
37.8
作者：
Lockhart, Peter B.;Brennan, Michael T.;Bahrani-Mougeot, Farah K.
通讯作者：
Bahrani-Mougeot, Farah K.
影响因子：
3
作者：
Nakano, K.;Nomura, R.;Ooshima, T.
通讯作者：
Ooshima, T.
影响因子：
120.7
作者：
Blumberg, RS;Strober, W
通讯作者：
Strober, W