Dynamic coupling between the central and autonomic nervous systems during sleep: A review.
Dynamic coupling between the central and autonomic nervous systems during sleep: A review.
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DOI：
10.1016/j.neubiorev.2018.03.027
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发表时间：
2018-07
影响因子：
8.2
通讯作者：
Baker FC
中科院分区：
文献类型：
--
作者：
de Zambotti M;Trinder J;Silvani A;Colrain IM;Baker FC
睡眠的特点是皮层和心脏的协调振荡，反映了中枢（CNS）和自主神经系统（ANS）之间的交流。在这里，我们回顾了与中枢神经系统定义的睡眠阶段和周期以及睡眠期间的阶段性皮质事件（如觉醒，k复合物）相关的ANS活动波动。近年来，新的分析方法揭示了睡眠过程中综合生理网络的动态组织，并指出了多种因素（如睡眠结构、年龄、睡眠障碍）如何影响“中枢-神经系统耦合”。然而，这些数据大多是相关的，并且缺乏潜在生理学的清晰度，使得解释因果关系和耦合方向具有挑战性。实验操作（例如，唤醒k复合物或唤醒）提供了关于皮质-心脏活动的精确时间序列的信息，并有助于研究中枢神经系统-中枢神经系统耦合背后的生理途径。随着新的分析方法的出现以及对睡眠期间ANS和CNS通信的重新关注，未来的工作可能会揭示健康和疾病期间睡眠和心血管相互作用的新见解，其中耦合可能受到不利影响。
Sleep is characterized by coordinated cortical and cardiac oscillations reflecting communication between the central (CNS) and autonomic (ANS) nervous systems. Here, we review fluctuations in ANS activity in association with CNS-defined sleep stages and cycles, and with phasic cortical events during sleep (e.g., arousals, K-complexes). Recent novel analytic methods reveal a dynamic organization of integrated physiological networks during sleep and indicate how multiple factors (e.g., sleep structure, age, sleep disorders) affect “CNS-ANS coupling”. However, these data are mostly correlational and there is a lack of clarity of the underlying physiology, making it challenging to interpret causality and direction of coupling. Experimental manipulations (e.g., evoking K-complexes or arousals) provide information on the precise temporal sequence of cortical-cardiac activity, and are useful for investigating physiological pathways underlying the CNS-ANS coupling. With the emergence of new analytical approaches and a renewed interest in ANS and CNS communication during sleep, future work may reveal novel insights into sleep and cardiovascular interactions during health and disease, in which coupling could be adversely impacted.
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