Fungal siderophore metabolism with a focus on Aspergillus fumigatus.
Fungal siderophore metabolism with a focus on Aspergillus fumigatus.
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DOI：
10.1039/c4np00071d
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发表时间：
2014-10
影响因子：
11.9
通讯作者：
Haas H
中科院分区：
文献类型：
--
作者：
Haas H
本重点内容概述了真菌铁载体代谢及其在生理学、细胞分化、与其他生物的相互作用以及潜在临床应用中的作用。
涵盖范围：截至2014年
铁载体是微生物合成的螯合剂，用于螯合铁。本文总结了有关真菌铁载体代谢的知识，重点关注烟曲霉。近年来，烟曲霉成为真菌铁载体生物合成、摄取和降解以及铁载体介导的铁处理调控和铁载体功能阐明的典范。铁载体的功能包括铁的摄取、细胞内运输和储存。这不仅对适应铁饥饿条件至关重要，而且对萌发、无性和有性繁殖、抗氧化防御、相互作用、微生物竞争以及在植物和动物宿主中的致病性也至关重要。近期研究还表明，铁载体及其生物合成途径在改进真菌感染的诊断和治疗方面具有很大潜力。
This Highlight provides an overview of fungal siderophore metabolism and its role in physiology, cellular differentiation, interaction with other organisms, as well as potential clinical applications. Covering: up to 2014 Siderophores are chelators synthesized by microbes to sequester iron. This article summarizes the knowledge on the fungal siderophore metabolism with a focus on Aspergillus fumigatus. In recent years, A. fumigatus became a role model for fungal biosynthesis, uptake and degradation of siderophores as well as regulation of siderophore-mediated iron handling and the elucidation of siderophore functions. Siderophore functions comprise uptake, intracellular transport and storage of iron. This proved to be crucial not only for adaptation to iron starvation conditions but also for germination, asexual and sexual propagation, antioxidative defense, mutual interaction, microbial competition as well as virulence in plant and animal hosts. Recent studies also indicate the high potential of siderophores and its biosynthetic pathway to improve diagnosis and therapy of fungal infections.
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影响因子：
3.6
作者：
Gründlinger M;Yasmin S;Lechner BE;Geley S;Schrettl M;Hynes M;Haas H
通讯作者：
Haas H
影响因子：
3.4
作者：
Bushley KE;Ripoll DR;Turgeon BG
通讯作者：
Turgeon BG
影响因子：
15
作者：
Frederick, Rosanne E.;Mayfield, Jeffery A.;DuBois, Jennifer L.
通讯作者：
DuBois, Jennifer L.
影响因子：
3
作者：
Allen, Gethin;Bromley, Mike;Turner, Geoffrey
通讯作者：
Turner, Geoffrey
影响因子：
3.6
作者：
Albarouki E;Schafferer L;Ye F;von Wirén N;Haas H;Deising HB
通讯作者：
Deising HB