Small-scale evaluation of the efficacy and residual activity of alpha-cypermethrin WG (250 g AI/kg) for indoor spraying in comparison with alpha-cypermethrin WP (50 g AI/kg) in India.

Small-scale evaluation of the efficacy and residual activity of alpha-cypermethrin WG (250 g AI/kg) for indoor spraying in comparison with alpha-cypermethrin WP (50 g AI/kg) in India.
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DOI:
10.1186/s12936-015-0739-7
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发表时间:
2015-05-29
期刊:
影响因子:
3
通讯作者:
Valecha N
Valecha N
中科院分区:
医学3区
文献类型:
--
作者:
Uragayala S;Kamaraju R;Tiwari S;Ghosh SK;Valecha N

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许多国家正在使用含有不同杀虫剂配方的室内滞留喷洒来控制蚊媒。在本研究中,在小规模(II期)田间试验中,比较了含甲-氯氰菊酯WG-SB(250 g AI/m2)制剂的IRS与WP制剂(50 g AI/kg)的残留效力和效力持续时间。采用20和30 mg AI/m2两种剂量对斯氏按蚊敏感种群进行了药效和持效期的评价。选择了四种类型的表面,即水泥墙与石膏涂层,水泥墙与石灰涂层,泥墙与石灰涂层,和砖墙未粉刷。用装有控制流量阀的哈德逊喷雾器进行喷雾。生物测定每周进行一次,然后每两周进行一次。从喷洒表面收集的滤纸样品的化学分析在比利时Gembloux的瓦隆农业研究所(Walloon Agricultural Research Institute)进行。甲-氯氰菊酯WG-SB在20 mg/m2剂量下表现出13-15周的残留效力(> 80%死亡率),在30 mg/m2剂量下表现出13-16周的残留效力,而甲-氯氰菊酯WP在20 mg/m2剂量下表现出11-15周的残留效力,在30 mg/m2剂量下表现出11-14周的残留效力。甲-氯氰菊酯WG-SB在20 mg AI/m2时的应用剂量与目标剂量比的平均值为0.89 - 1.17,WG-SB在30 mg AI/m2时为0.83-1.80,甲-氯氰菊酯WP在20 mg AI/m2时为0.87-1.66,WP在30 mg AI/m2时为0.68-1.06。在喷洒作业期间和之后,喷洒人员或住户均未报告不良事件。结果表明,WG 30 mg/m2的剂量在大多数常见的室内表面上对疟疾媒介具有稍长的有效残留作用(16周),可用于有效控制按蚊。发现WG制剂易于处理,喷洒过程中没有报告任何气味,并且发现对于室内滞留喷洒来说操作上可以接受。
Indoor residual spraying (IRS) with different formulations of insecticides is being used for the control of mosquito vectors in many countries. In the present study, residual efficacy and duration of effectiveness of IRS with alpha-cypermethrin WG-SB (250 g AI/m2) formulation was compared with WP formulation (50 g AI/kg) in a small scale (Phase II) field trial. Two dosages, i.e. 20 and 30 mg AI/m2, were used and the efficacy and duration of effectiveness was assessed on alpha-cypermethrin susceptible population of Anopheles stephensi. Four types of surfaces were selected, namely cement wall with distemper coating, cement wall with lime coating, mud wall with lime coating, and brick wall unpainted. Spraying was carried out with Hudson sprayer fitted with control flow valve. Bioassays were carried out at weekly and then fortnightly intervals. Chemical analysis of filter paper samples collected from the sprayed surfaces was done at Walloon Agricultural Research Institute, Gembloux, Belgium. Alpha-cypermethrin WG-SB showed residual efficacy (>80 % mortality) for 13–15 weeks for the 20 mg/m2 dosage and 13–16 weeks for the 30 mg/m2 dosage, whereas alpha-cypermethrin WP showed residual efficacy for 11–15 weeks for the 20 mg/m2 dosage and 11–14 weeks for the 30 mg/m2 dosage on the surfaces tested. The average of the applied to target dose ratio ranged from 0.89 to 1.17 for alpha-cypermethrin WG-SB at 20 mg AI/m2, 0.83–1.80 for the WG-SB at 30 mg AI/m2, 0.87–1.66 for alpha-cypermethrin WP at 20 mg AI/m2, and 0.68–1.06 for WP at 30 mg AI/m2. No adverse events were reported, either by the spray men or the household inhabitants, during and after the spray operations. The results suggest that the dose of WG 30 mg/m2 gave slightly longer effective residual action against malaria vector (16 weeks) on most common indoor surfaces and could be used for effective control of Anopheles mosquitoes. The WG formulation was found to be easy to handle, no smell was reported during the spraying and was found to be operationally acceptable for indoor residual spraying.
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作者:
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