Structural abnormalities in paediatric moyamoya disease revealed by clinical magnetic resonance imaging, regionally distributed relative signal intensities and volumes.
Structural abnormalities in paediatric moyamoya disease revealed by clinical magnetic resonance imaging, regionally distributed relative signal intensities and volumes.
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DOI：
10.1002/jdn.10167
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Levman J
中科院分区：
文献类型：
--
作者：
Ijner P;Tompkins G;Shiohama T;Takahashi E;Levman J
烟雾病（MMD）是一种罕见的进行性脑血管疾病，其病因和发病机制尚不清楚。其特征在于颈内动脉（伊卡）末端的狭窄闭塞性变化，伴有称为烟雾血管的基底侧支的可变发育。在这项研究中，我们调查的潜力，结构T1磁共振成像（MRI），以帮助表征MMD临床上，与区域分布的相对信号强度（RRSIs）和体积（RRVs）的帮助。这些RRSI和RRV提供了表征区域大脑发育方面的能力，并代表了对现有自动生物标志物提取技术的扩展。该研究包括来自MMD患者的269次MRI检查和来自神经典型对照的993次MRI检查，使用受试者工作特征曲线下面积（AUC）比较了两组之间的区域生物标志物。结果表明，RRSI和RRV在眼眶（15-20岁队列，左侧AUC：0.74，右侧AUC：0.71）和外侧眶额区（5-10岁队列，左侧AUC：0.67; 15-20岁队列，左侧AUC：0.62，右侧AUC：0.65）中存在异常。结果表明，RRSI和RRV可能有助于表征大脑发育，有助于评估MMD儿童大脑的表现，并可能有助于克服多协议临床MRI的标准化挑战。通过开源软件的发布，有必要对RRSI和RRV在临床成像中的潜力进行进一步研究。烟雾病（MMD）的特征是颈内动脉末端的狭窄闭塞性改变，导致进行性脑血管疾病。在这项研究中，我们调查的潜力区域相对体积（RRVs）和信号强度（RRSIs）提取的结构磁共振成像，以表征异常的神经发育MMD。结果显示异常的介绍，眶额区，尾状核。开放源码软件可供使用，以方便其他研究人员计算RRV和RRSI，作为未来研究的一部分。
Moyamoya disease (MMD) is a rare, progressive cerebrovascular disorder, with an unknown etiology and pathogenesis. It is characterized by steno-occlusive changes at the terminal portion of the internal carotid artery (ICA), which is accompanied by variable development of the basal collaterals called moyamoya vessels. In this study, we investigate the potential for structural T1 magnetic resonance imaging (MRI) to help characterize MMD clinically, with the help of regionally distributed relative signal intensities (RRSIs) and volumes (RRVs). These RRSIs and RRVs provide the ability to characterize aspects of regional brain development and represent an extension to existing automated biomarker extraction technologies. This study included 269 MRI examinations from MMD patients and 993 MRI examinations from neurotypical controls, with regional biomarkers compared between groups with the area under the receiver operating characteristic curve (AUC). Results demonstrate abnormal presentation of RRSIs and RRVs in the insula (15-20 year old cohort, left AUC: 0.74, right AUC: 0.71), and the lateral orbitofrontal region (5-10 year old cohort, left AUC: 0.67; 15-20 year cohort, left AUC: 0.62, right AUC: 0.65). Results indicate that RRSIs and RRVs may help in characterizing brain development, assist in the assessment of the presentation of the brains of children with MMD, and may help overcome standardization challenges in multi-protocol clinical MRI. Further investigation of the potential for RRSIs and RRVs in clinical imaging is warranted and supported through the release of open source software. Moyamoya disease (MMD) is characterized by steno-occlusive changes at the terminal portion of the internal carotid artery, resulting in a progressive cerebrovascular disorder. In this study, we investigate the potential for regional relative volumes (RRVs) and signal intensities (RRSIs) extracted from structural magnetic resonance imaging to characterize abnormal neurodevelopment in MMD. Results demonstrate abnormal presentation of the insula, the orbitofrontal region, and the caudate. Open source software is made available to facilitate other researchers in calculating RRVs and RRSIs as part of future studies.
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