Reduced gray to white matter tissue intensity contrast in schizophrenia.
Reduced gray to white matter tissue intensity contrast in schizophrenia.
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DOI：
10.1371/journal.pone.0037016
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Thomann PA
中科院分区：
文献类型：
--
作者：
Kong L;Herold C;Stieltjes B;Essig M;Seidl U;Wolf RC;Wüstenberg T;Lässer MM;Schmid LA;Schnell K;Hirjak D;Thomann PA
虽然许多结构磁共振成像（MRI）的研究表明，脑体积或密度，皮质厚度和纤维完整性的变化，精神分裂症，组织改变的神经结构的对比度性能的影响，迄今为止仍然大多未被探索。在3特斯拉的全脑高分辨率MRI被用来研究精神分裂症患者和健康对照组的组织对比度和皮质厚度。患者在整个皮质覆盖层的大部分区域中显示出灰至白色物质对比度显著降低，在下、中、上级和内侧颞区以及外侧和内侧额叶区域中占优势。这些强度对比度变化的程度超过了皮质变薄的程度。此外，对比度的变化仍然显着控制皮质厚度测量后。我们的研究结果清楚地强调了精神分裂症相关脑组织变化的存在，这些变化改变了脑结构的成像特性。强度对比度测量可能不仅作为一个高度敏感的度量，而且作为一个独特的病理过程，可能是独立于体积或厚度变化的潜在指标。
While numerous structural magnetic resonance imaging (MRI) studies revealed changes of brain volume or density, cortical thickness and fibre integrity in schizophrenia, the effect of tissue alterations on the contrast properties of neural structures has so far remained mostly unexplored. Whole brain high-resolution MRI at 3 Tesla was used to investigate tissue contrast and cortical thickness in patients with schizophrenia and healthy controls. Patients showed significantly decreased gray to white matter contrast in large portions throughout the cortical mantle with preponderance in inferior, middle, superior and medial temporal areas as well as in lateral and medial frontal regions. The extent of these intensity contrast changes exceeded the extent of cortical thinning. Further, contrast changes remained significant after controlling for cortical thickness measurements. Our findings clearly emphasize the presence of schizophrenia related brain tissue changes that alter the imaging properties of brain structures. Intensity contrast measurements might not only serve as a highly sensitive metric but also as a potential indicator of a distinct pathological process that might be independent from volume or thickness alterations.
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影响因子：
5.7
作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
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Fischl B
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5.7
作者：
Giorgio, Antonio;Santelli, Luca;Tomassini, Valentina;Bosnell, Rose;Smith, Steve;De Stefano, Nicola;Johansen-Berg, Heidi
通讯作者：
Johansen-Berg, Heidi
影响因子：
2.8
作者：
Baas, PW
通讯作者：
Baas, PW
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J