Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice.
Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice.
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DOI：
10.1016/j.neuron.2020.09.012
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发表时间：
2020-12-09
期刊：
影响因子：
16.2
通讯作者：
Hires SA
中科院分区：
文献类型：
--
作者：
Kim J;Erskine A;Cheung JA;Hires SA
触觉形状识别需要对物体表面角度的感知。我们研究了如何从感官输入构建对象角度的神经表征，以及它们如何在学习过程中重组。头部固定的小鼠通过用一根胡须主动探索来学习辨别物体的角度。桶状皮质2-4层的钙成像显示了学习前后的对象角度调整图。三维晶须跟踪表明，感觉输入组件，最好的歧视角度（垂直弯曲和滑动距离）也有最大的影响对象的角度调整。尽管在整个学习过程中，活跃的集成成员的更替率很高，但对象角度调谐偏好的人口分布仍然保持稳定。角度调谐变得尖锐，但仅限于偏好训练角度的神经元。这与选择性增加的影响，最相关的任务的感官组件对对象的角度调整。这些结果显示了辨别训练如何增强初级躯体感觉皮层的刺激选择性，同时保持知觉稳定性。触觉形状识别需要对物体表面角度的感知。Kim等人展示了初级躯体感觉皮层中的兴奋性神经元如何从感觉输入成分构建物角表征。任务相关的感觉成分获得的影响，对象角度调整角度辨别训练，符合训练的角度表征的选择性锐化。
Tactile shape recognition requires the perception of object surface angles. We investigate how neural representations of object angles are constructed from sensory input and how they reorganize across learning. Head-fixed mice learned to discriminate object angles by active exploration with one whisker. Calcium imaging of layers 2–4 of the barrel cortex revealed maps of object-angle tuning before and after learning. Three-dimensional whisker tracking demonstrated that the sensory input components that best discriminate angles (vertical bending and slide distance) also have the greatest influence on object-angle tuning. Despite the high turnover in active ensemble membership across learning, the population distribution of object-angle tuning preferences remained stable. Angle tuning sharpened, but only in neurons that preferred trained angles. This was correlated with a selective increase in the influence of the most task-relevant sensory component on object-angle tuning. These results show how discrimination training enhances stimulus selectivity in the primary somatosensory cortex while maintaining perceptual stability. Tactile shape recognition requires the perception of object surface angles. Kim et al. show how excitatory neurons in the primary somatosensory cortex construct object-angle representations from sensory input components. Task-relevant sensory components gain influence on object-angle tuning across angle discrimination training, coincident with selective sharpening of trained angle representations.
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DOI：
10.1126/science.aab3415
发表时间：
2015-09-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dehorter N;Ciceri G;Bartolini G;Lim L;del Pino I;Marín O
通讯作者：
Marín O
影响因子：
5.3
作者：
Barth, AL;Gerkin, RC;Dean, KL
通讯作者：
Dean, KL
影响因子：
9.2
作者：
Furuta, Takahiro;Bush, Nicholas E.;Yang, Anne En-Tzu;Ebara, Satomi;Miyazaki, Naoyuki;Murata, Kazuyoshi;Hirai, Daichi;Shibata, Ken-ichi;Hartmann, Mitra J. Z.
通讯作者：
Hartmann, Mitra J. Z.
影响因子：
64.8
作者：
Coste, Bertrand;Xiao, Bailong;Santos, Jose S.;Syeda, Ruhma;Grandl, Joerg;Spencer, Kathryn S.;Kim, Sung Eun;Schmidt, Manuela;Mathur, Jayanti;Dubin, Adrienne E.;Montal, Mauricio;Patapoutian, Ardem
通讯作者：
Patapoutian, Ardem
影响因子：
5.3
作者：
Bensmaia, Sliman J.;Denchev, Peter V.;Hsiao, Steven S.
通讯作者：
Hsiao, Steven S.