Posttraining Inactivation of Excitatory Afferent Input to the Locus Coeruleus Impairs Retention in an Inhibitory Avoidance Learning Task
Posttraining Inactivation of Excitatory Afferent Input to the Locus Coeruleus Impairs Retention in an Inhibitory Avoidance Learning Task
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训练后蓝斑兴奋性传入输入失活会损害抑制性回避学习任务的记忆力
DOI：
--
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发表时间：
2000
影响因子：
2.7
通讯作者：
Cedric L. Williams
中科院分区：
文献类型：
--
作者：
E. Clayton;Cedric L. Williams
这些实验研究了旁巨细胞核（PGi）是否有助于记忆存储处理通过其上行兴奋性影响蓝斑（LC）神经元活动。LC的激活导致记忆增强，并且还导致去甲肾上腺素在靶结构（例如杏仁核和海马体）中的广泛释放。将去甲肾上腺素注入这两种结构中的任何一种，都能改善对几种习得反应的记忆。因此，去甲肾上腺素调节边缘结构内记忆的能力可能取决于PGi和LC之间的功能连接。为了检验这一假设，雄性Sprague-Dawley大鼠植入套管，套管对准PGi上方（实验1和2）或PGi背侧或内侧1.5 mm（实验3）。在抑制性回避训练（0.45mA，0. 5s）、磷酸盐缓冲盐水、利多卡因（实验1）或12.5或25 nmol/0.5 μ l的GABA激动剂蝇蕈醇（实验2）注入PGi。在48小时后进行的保留测试中，与对照组相比，给予利多卡因或12.5或25.0 nmol蝇蕈醇的受试者重新进入足电击室的潜伏期显著缩短。在实验3中，将利多卡因或蝇蕈醇注入PGi背侧或内侧1.5 mm的区域并没有显着改变保留，这表明实验1和2中观察到的记忆障碍是部位特异性的，而不是由于药物扩散到PGi周围的细胞群。这些发现表明，PGi可能通过其对LC的兴奋性影响，在将生物学相关信息传递到参与记忆的前脑结构中发挥重要作用。
These experiments examined whether the nucleus paragigantocellularis (PGi) contributes to memory storage processing via its ascending excitatory influence on locus coeruleus (LC) neuronal activity. Activation of the LC leads to memory enhancement and also results in a widespread release of norepinephrine in target structures, such as the amygdala and hippocampus. Infusion of norepinephrine into either structure also improves memory for several types of learned responses. Thus, the capacity for norepinephrine to modulate memory within limbic structures may be contingent upon the functional connections between PGi and the LC. To examine this hypothesis, male Sprague-Dawley rats were implanted with cannula aimed above PGi (Experiments 1 and 2) or 1.5 mm dorsal or medial to PGi (Experiment 3). Immediately following inhibitory avoidance training (0.45 mA, 0. 5 s), phosphate-buffered saline, lidocaine (Experiment 1), or 12.5 or 25 nmol/0.5 microl of the GABA agonist muscimol (Experiment 2) was infused into PGi. On a retention test given 48 h later, the latency to reenter the footshock compartment was significantly shorter for subjects given either lidocaine or 12.5 or 25.0 nmol of muscimol compared to controls. In Experiment 3, infusion of lidocaine or muscimol into areas 1.5 mm dorsal or medial to PGi did not significantly alter retention, indicating that the memory impairment observed in Experiments 1 and 2 was site specific and not due to the spread of drug to cell groups surrounding PGi. These findings suggest that PGi may serve a vital function in relaying biologically relevant information to forebrain structures involved in memory via its excitatory influence on the LC.
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影响因子：
--
作者：
Gary Aston-Jones;C. Chiang;T. Alexinsky
通讯作者：
Gary Aston-Jones;C. Chiang;T. Alexinsky
孤束核的可逆性损伤会减弱训练后肾上腺素的记忆调节作用。
影响因子：
1.9
作者：
Williams,CL;McGaugh,JL
通讯作者：
McGaugh,JL
GABA 介导的压力感受器抑制网状脊髓神经元。
DOI：
10.1152/ajpregu.1985.249.6.r672
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Sun,MK;Guyenet,PG
通讯作者：
Guyenet,PG
影响因子：
56.9
作者：
ASTONJONES, G;ENNIS, M;SHIPLEY, MT
通讯作者：
SHIPLEY, MT