Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review.
Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review.
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益生菌作为预防和治疗过敏的可能策略。叙事评论。
DOI：
10.3390/foods10040701
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发表时间：
2021-03-25
期刊：
影响因子：
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通讯作者：
Miranda JM
中科院分区：
文献类型：
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作者：
Lopez-Santamarina A;Gonzalez EG;Lamas A;Mondragon ADC;Regal P;Miranda JM
过敏是一个日益严重的全球公共卫生问题，特别是对于儿童和生活在城市环境中的人们。过敏症损害了那些患有过敏症的人的生活质量，因此，正在寻找治疗过敏性疾病或减轻其症状的替代方案。这项研究的主要目的是汇编对益生菌作为过敏症的可能治疗方法进行的研究。研究最多的过敏症，益生菌已被证明有一个有益的影响是鼻炎，哮喘和特应性皮炎。大多数研究已经研究了乳酸杆菌和双歧杆菌属的管理。并且已经显示出有益的效果，例如降低由过敏原引起的高反应性和炎症以及减少细胞因子释放，以及其他有益的效果。在儿童的情况下，在几项研究中没有发现明确的有益效果，并且使用一些机会性细菌（如益生菌）的潜在风险似乎存在争议。在报告有益结果的研究中，发现这些作用可以降低过敏症状的侵袭性，从而降低过敏患者的发病率。相同益生菌对不同患者的不同作用似乎强化了益生菌的功效取决于微生物物种或菌株、其衍生的代谢物和副产物以及患者的肠道微生物群生态良好的想法。这项研究在过敏性疾病的背景下是相关的，因为它提供了一个更广泛的了解新的替代治疗过敏，无论是在儿童，谁是主要的患者，和成人，表明益生菌，在某些情况下，减少症状和严重程度的这类疾病。
Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.
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影响因子：
4.3
作者：
Anatriello, E.;Cunha, M.;Aimbire, F.
通讯作者：
Aimbire, F.
影响因子：
12.4
作者：
Boyle, R. J.;Ismail, I. H.;Tang, M. L. K.
通讯作者：
Tang, M. L. K.
影响因子：
5.1
作者：
Canani, Roberto Berni;Nocerino, Rita;Troncone, Riccardo
通讯作者：
Troncone, Riccardo
影响因子：
11.8
作者：
Doron, Shira;Snydman, David R.
通讯作者：
Snydman, David R.
DOI：
10.1111/j.1365-2222.2006.02463.x
发表时间：
2006-04
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
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作者：
通讯作者：
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