Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear, anisotropic, and time-dependent.
Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear, anisotropic, and time-dependent.
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DOI：
10.1016/j.jbiomech.2014.06.008
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发表时间：
2014-08-22
影响因子：
2.4
通讯作者：
Elliott, Dawn M.
中科院分区：
文献类型：
--
作者：
Jacobs, Nathan T.;Cortes, Daniel H.;Peloquin, John M.;Vresilovic, Edward J.;Elliott, Dawn M.
关键词：
有限元（FE）模型在椎间盘力学研究中是有利的，因为可以确定整个组织的应力-应变分布，并且可以控制和修改施加的载荷和材料特性。然而，盘的复杂性质提出了一个挑战，在开发一个准确的和预测的盘模型，这导致了有限的FE几何形状，材料本构模型和属性，模型验证。本研究的目的是开发一种新的椎间盘有限元模型，以验证模型的非线性和时间依赖性的响应，无需调整或校准，并评估髓核（NP），软骨终板（CEP）和纤维环（AF）材料特性的变化对椎间盘力学响应的影响。新的FE椎间盘模型采用基于分析的几何结构。该模型是从人类L4/L5椎间盘的平均形状创建的，从高分辨率3D MR图像测量，并使用符号距离函数求平均值。结构超弹性本构模型与双相膨胀理论结合使用，以获得最近的组织测试在侧限压缩和单轴拉伸的材料性能。对于压缩缓慢加载斜坡、蠕变和应力松弛模拟，FE圆盘模型预测在圆盘非线性响应的实验范围内（平均值± 95%置信区间）。NP和CEP性质的变化影响中性区位移，但在缓慢斜坡压缩加载过程中的最终刚度几乎没有影响。这些结果突出了需要验证有限元模型使用光盘的完整的非线性响应在多个负载的情况下。
Finite element (FE) models are advantageous in the study of intervertebral disc mechanics as the stress–strain distributions can be determined throughout the tissue and the applied loading and material properties can be controlled and modified. However, the complicated nature of the disc presents a challenge in developing an accurate and predictive disc model, which has led to limitations in FE geometry, material constitutive models and properties, and model validation. The objective of this study was to develop a new FE model of the intervertebral disc, to validate the model’s nonlinear and time-dependent responses without tuning or calibration, and to evaluate the effect of changes in nucleus pulposus (NP), cartilaginous endplate (CEP), and annulus fibrosus (AF) material properties on the disc mechanical response. The new FE disc model utilized an analytically-based geometry. The model was created from the mean shape of human L4/L5 discs, measured from high-resolution 3D MR images and averaged using signed distance functions. Structural hyperelastic constitutive models were used in conjunction with biphasic-swelling theory to obtain material properties from recent tissue tests in confined compression and uniaxial tension. The FE disc model predictions fit within the experimental range (mean ± 95% confidence interval) of the disc’s nonlinear response for compressive slow loading ramp, creep, and stress-relaxation simulations. Changes in NP and CEP properties affected the neutral-zone displacement but had little effect on the final stiffness during slow-ramp compression loading. These results highlight the need to validate FE models using the disc’s full nonlinear response in multiple loading scenarios.
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DOI：
10.1002/jor.22355
发表时间：
2013-08
期刊：
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
影响因子：
--
作者：
Martin JT;Gorth DJ;Beattie EE;Harfe BD;Smith LJ;Elliott DM
通讯作者：
Elliott DM
DOI：
10.1080/10255842.2010.493522
发表时间：
2011-01-01
影响因子：
1.6
作者：
Galbusera, Fabio;Schmidt, Hendrik;Wilke, Hans-Joachim
通讯作者：
Wilke, Hans-Joachim
影响因子：
2.8
作者：
Moon, Sung M.;Yoder, Jonathon H.;Elliott, Dawn M.
通讯作者：
Elliott, Dawn M.
影响因子：
2.4
作者：
Jaime Garcia, Jose;Humberto Cortes, Daniel
通讯作者：
Humberto Cortes, Daniel
影响因子：
2.4
作者：
Guerin, Heather Anne L.;Elliott, Dawn M.
通讯作者：
Elliott, Dawn M.