Kidney development: from ureteric bud formation to branching morphogenesis.

Kidney development: from ureteric bud formation to branching morphogenesis.
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肾脏发育:从输尿管芽形成到分支形态发生。

DOI:
10.1016/j.gde.2009.09.003
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发表时间:
2009-10
影响因子:
4
通讯作者:
Michos, Odysse
Michos, Odysse
中科院分区:
生物学2区
文献类型:
--
作者:
Michos, Odysse

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上皮分支形态发生对于脊椎动物胚胎中各种器官的形成至关重要,例如脉管系统、乳腺、肺和肾。分支形态发生的一个令人着迷的方面是了解简单的上皮管如何通过反复分支生长形成复杂的上皮树结构。最近的研究将小鼠遗传学和嵌合分析与实时成像相结合,揭示了控制肾分支形态发生的分子网络和相互作用。本综述重点关注肾脏发育过程中的输尿管芽形成和上皮分支。输尿管芽侵入后肾间质是建立肾脏细胞结构和确定肾单位数量的基本步骤,肾单位形成成人肾脏的过滤单位。
Epithelial branching morphogenesis is critical to formation of various organs such as the vasculature, mammary glands, lungs and kidneys in vertebrate embryos. One fascinating aspect of branching morphogenesis is to understand how a simple epithelial tube grows by reiterative branching to form a complex epithelial tree structure. Recent studies combining mouse genetics and chimeric analysis with live imaging have uncovered the molecular networks and interactions that govern kidney branching morphogenesis. This review focuses on ureteric bud formation and epithelial branching during kidney development. The invasion of the metanephric mesenchyme by the ureteric bud is a fundamental step towards establishing the cyto-architecture of the kidney and determining the number of nephrons, which form the filtration units of the adult kidney.
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