Developmental genetic evidence for a monophyletic origin of the bilaterian brain.
Developmental genetic evidence for a monophyletic origin of the bilaterian brain.
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两侧对称动物大脑单系起源的发育遗传证据。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
A. Simeone
中科院分区：
文献类型：
--
作者：
H. Reichert;A. Simeone
无脊椎动物和脊椎动物脑的独立进化起源的广泛持有的概念是基于经典的系统发育，神经解剖学和胚胎学数据。这些数据的解释，有利于动物大脑的多系起源目前受到挑战的三个基本的调查结果，来自比较分子，遗传和发育分析。首先，现代分子系统学表明，没有一种现存动物对应于原口动物和后口动物之间的进化中间体，因此不可能从现存物种中推断出祖先两侧动物或其大脑的形态组织。其次，最近的分子遗传学证据的身体轴倒置假说现在支持的想法，脊椎动物和无脊椎动物的基本身体计划是相似的，但倒置，这表明腹神经索的原口无脊椎动物是同源的背神经索的后口脊索动物。第三，对早期胚胎脑模式化中所涉及的分子控制元件的发育遗传学分析揭示了在无脊椎动物和脊椎动物模型系统中，在脑发育的关键方面具有可比和可互换功能的结构和功能同源基因的存在。所有这三个发现都与双侧脑的单系起源假说相一致。在这里，我们回顾这些研究结果，并考虑其意义和影响目前的思想的进化起源的双侧脑。我们还预览了比较功能基因组分析对我们理解大脑进化的影响。
The widely held notion of an independent evolutionary origin of invertebrate and vertebrate brains is based on classical phylogenetic, neuroanatomical and embryological data. The interpretation of these data in favour of a polyphyletic origin of animals brains is currently being challenged by three fundamental findings that derive from comparative molecular, genetic and developmental analyses. First, modern molecular systematics indicates that none of the extant animals correspond to evolutionary intermediates between the protostomes and the deuterostomes, thus making it impossible to deduce the morphological organization of the ancestral bilaterian or its brain from living species. Second, recent molecular genetic evidence for the body axis inversion hypothesis now supports the idea that the basic body plan of vertebrates and invertebrates is similar but inverted, suggesting that the ventral nerve chord of protostome invertebrates is homologous to the dorsal nerve cord of deuterostome chordates. Third, a developmental genetic analysis of the molecular control elements involved in early embryonic brain patterning is uncovering the existence of structurally and functionally homologous genes that have comparable and interchangeable functions in key aspects of brain development in invertebrate and vertebrate model systems. All three of these findings are compatible with the hypothesis of a monophyletic origin of the bilaterian brain. Here we review these findings and consider their significance and implications for current thinking on the evolutionary origin of bilaterian brains. We also preview the impact of comparative functional genomic analyses on our understanding of brain evolution.
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影响因子：
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作者：
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通讯作者：
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