Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome.

Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome.
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肌力性脑脊髓炎/慢性疲劳综合征的见解可能有助于揭示急性Covid-19综合征的发病机理。

DOI:
10.1016/j.molmed.2021.06.002
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发表时间:
2021-09
影响因子:
13.6
通讯作者:
Lipkin WI
Lipkin WI
中科院分区:
医学1区
文献类型:
--
作者:
Komaroff AL;Lipkin WI

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严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)可引起慢性和急性疾病。SARS-CoV-2感染(PASC)的急性后后遗症包括肺、心脏、肾脏和大脑的损伤,可能会产生各种症状。PASC还包括2019年冠状病毒后疾病(COVID-19)综合征(“长COVID”),其特征可能与其他急性传染病和肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)相似。本文总结了ME/CFS和“急性”COVID-19的发病机制,并推测部分人群的后COVID-19综合征的发病机制可能与ME/CFS相似。我们提出了可能解释这两种疾病中疲劳和相关症状的分子机制,并提出了针对ME/CFS和covid -19后综合征的研究议程。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause chronic and acute disease. Postacute sequelae of SARS-CoV-2 infection (PASC) include injury to the lungs, heart, kidneys, and brain that may produce a variety of symptoms. PASC also includes a post–coronavirus disease 2019 (COVID-19) syndrome (‘long COVID’) with features that can follow other acute infectious diseases and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here we summarize what is known about the pathogenesis of ME/CFS and of ‘acute’ COVID-19, and we speculate that the pathogenesis of post–COVID-19 syndrome in some people may be similar to that of ME/CFS. We propose molecular mechanisms that might explain the fatigue and related symptoms in both illnesses, and we suggest a research agenda for both ME/CFS and post–COVID-19 syndrome.
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