Prevalence of allergen-specific IgE in southern China: a multicenter research.

Prevalence of allergen-specific IgE in southern China: a multicenter research.
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中国南方地区过敏原特异性 IgE 的患病率:一项多中心研究

DOI:
10.18632/aging.203341
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发表时间:
2021-07-22
期刊:
Aging
影响因子:
--
通讯作者:
Yang B
Yang B
中科院分区:
其他
文献类型:
--
作者:
Wang X;Zhou L;Wei G;Zhang H;Yang B

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识别过敏原分布对于过敏性疾病的有效诊断和治疗具有重要意义。本研究比较了中国南方四个城市的过敏原敏感性。 2007 年至 2019 年间,我们招募了 55,432 名参与者(27,408 名男性,28,024 名女性)。通过 χ2 检验比较过敏原特异性 IgE 水平。五种最常见的敏感性是螨类混合物(10,985,19.82%)、蟑螂(4,860,8.77%)、螃蟹(4,450,8.03%)、鱼类混合物(3,874,6.99%)和室内灰尘(3,486,6.29%)。几乎所有过敏原敏感性都会随着年龄的增长而降低,特别是从婴儿到中年参与者(p < 0.05)。深圳是个例外,该市所有研究年龄组的食物过敏原阳性率均保持不变。在所有四个城市中,对至少一种食物过敏原(OR 1.130;95% CI 1.088–1.174,p < 0.0025)或空气过敏原(OR,1.117;95% CI,1.078–1.158,p < 0.0025)敏感的男性比例均高于女性。除狗皮屑和树木混合物外,所有空气过敏原在季节之间均存在显着差异(p < 0.05)。柳州的食物过敏原和空气过敏原阳性参与者比例最高。所研究城市之间的过敏原特异性 IgE 分布不同,具有显着的季节性差异。年轻、男性和空气过敏原是过敏性疾病的危险因素。
Identifying allergen distribution is meaningful and significant for effective diagnosis and treatment of allergic diseases. This study compared the allergen sensitivity in four southern China cities. We enrolled 55,432 participants (27,408 male, 28,024 female) between 2007 and 2019. The allergen-specific IgE levels were compared by the χ2 test. The five prevalent sensitivities were for mite mix (10,985, 19.82%), cockroach (4,860, 8.77%), crab (4,450, 8.03%), fish mix (3,874, 6.99%), and house dust (3,486, 6.29%). Almost all allergen sensitivities decreased with age, particularly from infant to middle aged participants (p < 0.05). An exception was Shenzhen, where food allergen positive rates remained constant in all age groups studied. The proportion of male sensitive to at least one food allergen (OR 1.130; 95% CI 1.088–1.174, p < 0.0025) or aeroallergen (OR, 1.117; 95% CI, 1.078–1.158, p < 0.0025) was higher than female in all four cities. Except for dog dander and tree mix, all aeroallergens differed significantly between seasons (p < 0.05). Liuzhou had the highest rates of food allergen- and aeroallergen-positive participants. The allergen-specific IgE distribution differed among the studied cities, with significant seasonal differences. Young age, male sex, and aeroallergens were risk factors for allergic disease.
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