Localized accumulation of lead within and among bones from lead-dosed goats.
Localized accumulation of lead within and among bones from lead-dosed goats.
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DOI：
10.1016/j.envres.2009.09.005
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发表时间：
2010-01
影响因子：
8.3
通讯作者：
Parsons, Patrick J.
中科院分区：
文献类型：
--
作者：
Cretacci, Yan;Parsons, Patrick J.
The principal aim of this study was to gain a better understanding of where lead (Pb) accumulates and how it is distributed, within the bones of dosed goats. Adult goats were periodically dosed with Pb over a number of years for the primary purpose of producing blood pools containing endogenously bound Pb, for the New York State Blood Lead Proficiency Testing Program. Bone samples (e.g., primarily tibia, femur, humerus, and radius) were collected post-mortem from 11 animals and were analyzed for Pb content by acid digestion and electrothermal atomic absorption spectrometry (ETAAS or GFAAS). Average tibia-Pb levels were found to correlate strongly with the cumulative Pb dose (r2 = 0.81). However, the concentration of Pb in different bones and even within a small area of the same bone varied tremendously. Blood-rich trabecular (spongy) bone, such as the patella and calcaneus, were much more enriched in Pb than was cortical (compact) bone. In some dosed animals, the Pb concentration in the tibia was markedly higher at the proximal and distal ends of the bone compared to the mid-shaft. The implications of these findings with regard to the non-invasive measurement of lead in bone by XRF methods are discussed.
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影响因子：
3.5
作者：
Todd, AC;Parsons, PJ;Moshier, EL
通讯作者：
Moshier, EL
影响因子：
10.4
作者：
Barbosa F Jr;Tanus-Santos JE;Gerlach RF;Parsons PJ
通讯作者：
Parsons PJ
影响因子：
3.4
作者：
Bellis, David J.;Li, Danhong;Parsons, Patrick J.
通讯作者：
Parsons, Patrick J.
影响因子：
10.4
作者：
Miranda ML;Kim D;Galeano MA;Paul CJ;Hull AP;Morgan SP
通讯作者：
Morgan SP
影响因子：
1.2
作者：
Parsons, P. J.;Bellis, D. J.;Todd, A. C.
通讯作者：
Todd, A. C.