Social reactivation of fear engrams enhances memory recall.
Social reactivation of fear engrams enhances memory recall.
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DOI：
10.1073/pnas.2114230119
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发表时间：
2022-03-22
影响因子：
11.1
通讯作者：
Ramirez S
中科院分区：
文献类型：
--
作者：
Finkelstein AB;Leblanc H;Cole RH;Gallerani T;Vieira A;Zaki Y;Ramirez S
社交互动可以增强和保护记忆力。然而，社会刺激和个人学习记忆之间的关系仍然是个谜。我们的工作表明，暴露于一个强调的，天真的nonfamiliar同种或环境的嗅觉听觉线索最近强调熟悉同种诱导海马中的恐惧记忆相关的细胞系综的重新激活。在社会经验中，对海马体进行刺激会引起先前获得负面记忆的动物的恐惧行为，揭示了个体历史和社会经验之间的相互作用。在社会经验中，恐惧驱动的神经复苏导致恐惧回忆的特定背景增强。我们的研究结果提供了证据表明，与直接压力源不同，社会刺激会重新激活和放大个人的记忆。对于群居动物来说，社会环境提供了显著的经验，可以削弱或加强认知的各个方面，如记忆回忆。虽然在齿状回（DG）和基底外侧杏仁核（BLA）的个体获得的恐惧记忆的细胞基质已经得到了很好的研究，最近的工作已经揭示了电路机制编码的社会经验，社会经验与个人的记忆相互作用，改变回忆的过程仍然未知。在这里，我们表明，压力的社会经验，提高了回忆先前获得的恐惧记忆在男性，但不是女性小鼠，和社会缓冲同种的痛苦块这种增强。在恐惧学习过程中DG中细胞的活动依赖性标记显示，这些集合在男性的社会经历中被内源性地重新激活，即使在灭绝之后。这些重新激活的细胞被证明是记忆痕迹的功能成分，因为在先前恐惧条件反射和不幼稚的动物中，在社会体验期间活跃的细胞的光遗传学刺激足以驱动与恐惧相关的行为。总之，我们的研究结果表明，社会经验可以重新激活先前存在的记忆痕迹，从而加强离散的记忆。
Social interactions can bolster and protect memory performance. However, the relationship between social stimuli and individually learned memories remains enigmatic. Our work reveals that exposure to a stressed, naïve nonfamiliar conspecific or to the ambient olfactory–auditory cues of a recently stressed familiar conspecific induces reactivation of the cellular ensembles associated with a fear memory in the hippocampus. Artificially stimulating the hippocampal ensemble active during the social experience induces fearful behaviors in animals that have previously acquired a negative memory, revealing the interaction between individual history and social experience. The neural resurgence of fear-driving ensembles during social experiences leads to a context-specific enhancement of fear recall. Our findings provide evidence that unlike direct stressors, social stimuli reactivate and amplify an individual’s memories. For group-living animals, the social environment provides salient experience that can weaken or strengthen aspects of cognition such as memory recall. Although the cellular substrates of individually acquired fear memories in the dentate gyrus (DG) and basolateral amygdala (BLA) have been well-studied and recent work has revealed circuit mechanisms underlying the encoding of social experience, the processes by which social experience interacts with an individual’s memories to alter recall remain unknown. Here we show that stressful social experiences enhance the recall of previously acquired fear memories in male but not female mice, and that social buffering of conspecifics’ distress blocks this enhancement. Activity-dependent tagging of cells in the DG during fear learning revealed that these ensembles were endogenously reactivated during the social experiences in males, even after extinction. These reactivated cells were shown to be functional components of engrams, as optogenetic stimulation of the cells active during the social experience in previously fear-conditioned and not naïve animals was sufficient to drive fear-related behaviors. Taken together, our findings suggest that social experiences can reactivate preexisting engrams to thereby strengthen discrete memories.
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DOI：
10.1038/s41583-020-0350-y
发表时间：
2020-10
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gothard KM
通讯作者：
Gothard KM
从杏仁核中的电路到行为。
影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
影响因子：
16.2
作者：
Duvarci S;Pare D
通讯作者：
Pare D
影响因子：
9.2
作者：
Chen, Briana K.;Murawski, Nathen J.;Ramirez, Steve
通讯作者：
Ramirez, Steve
影响因子：
2.8
作者：
Dutton, Courtney E.;Rojas, Sasha M.;Feldner, Matthew T.
通讯作者：
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