Attenuated Post-Movement Beta Rebound Associated With Schizotypal Features in Healthy People.
Attenuated Post-Movement Beta Rebound Associated With Schizotypal Features in Healthy People.
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DOI：
10.1093/schbul/sby117
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发表时间：
2019-06-18
影响因子：
6.6
通讯作者：
Liddle PF
中科院分区：
文献类型：
--
作者：
Hunt BAE;Liddle EB;Gascoyne LE;Magazzini L;Routley BC;Singh KD;Morris PG;Brookes MJ;Liddle PF
精神分裂症和典型人格障碍（SPD）属于单一的精神疾病谱，有证据表明这两种疾病的病因相似。然而，在健康人群中，体型是人格的异质性方面，因此可以被视为健康和精神疾病之间的桥梁。这种连续性的神经证据将对精神分裂症的特征和治疗产生影响。基于我们以前的工作，确定精神分裂症的神经系统学和异常运动诱导的电生理反应（运动后β反弹[PMBR]）之间的关系，我们预测，如果亚临床神经系统型源于与精神分裂症相似的神经机制，健康个体的神经系统型将与PMBR降低相关。116名参与者完成了视觉任务，同时他们的神经活动被脑磁图记录下来。从左侧初级运动皮层提取的PMBR测量值与分裂型人格问卷（SPQ）（一种自我报告的分裂型人格测量）的分数之间的偏相关性进行了计算。PMBR和SPQ因子分数测量的认知知觉，人际关系和混乱的尺寸的仿形之间的相关性也进行了计算。控制部位、年龄和性别的影响。我们发现SPQ总分和PMBR之间存在显著的负相关。这是最强烈的调解之间的差异共享人际和混乱的因素得分。这些研究结果表明，一个连续的神经缺损之间的神经型和精神分裂症，减少PMBR，以前报告的精神分裂症，也可测量的个人与神经型的功能，特别是混乱和受损的人际关系。
Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the 2 conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound [PMBR]), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR. One-hundred sixteen participants completed a visuomotor task while their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring cognitive-perceptual, interpersonal and disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for. We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between interpersonal and disorganization factor scores. These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations.
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影响因子：
4.5
作者：
Bollini, Annie M.;Compton, Michael T.;Walker, Elaine F.
通讯作者：
Walker, Elaine F.
影响因子：
5.7
作者：
Brookes MJ;Tewarie PK;Hunt BAE;Robson SE;Gascoyne LE;Liddle EB;Liddle PF;Morris PG
通讯作者：
Morris PG
影响因子：
10.5
作者：
CLARIDGE, G
通讯作者：
CLARIDGE, G
影响因子：
2.4
作者：
Asai, Tomohisa;Sugimori, Eriko;Tanno, Yoshihiko
通讯作者：
Tanno, Yoshihiko
影响因子：
3.3
作者：
Mougin, Olivier;Abdel-Fahim, Rasha;Gowland, Penny
通讯作者：
Gowland, Penny