When three is not a crowd: a Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells
When three is not a crowd: a Crossregulation Model of the dynamics and repertoire selection of regulatory CD4+ T cells
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当三个人不成群时：调节性 CD4 T 细胞动态和库选择的交叉调节模型
DOI：
10.1111/j.1600-065x.2007.00487.x
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发表时间：
2007
影响因子：
8.7
通讯作者：
J. Demengeot
中科院分区：
文献类型：
--
作者：
J. Carneiro;K. Leon;I. Caramalho;C. van den Dool;Rui Gardner;V. Oliveira;M. Bergman;N. Sepúlveda;T. Paixão;J. Faro;J. Demengeot
摘要： 健康个体的 CD25 池中富含调节性 CD4+ T 细胞，可介导自然耐受并预防自身免疫性疾病。尽管调节性 T (TR) 细胞具有基础和潜在的临床意义，但它们尚未被纳入免疫系统的连贯理论中。本文回顾了支持 TR 细胞动力学模型的实验证据和理论论证，揭示了一些最相关的生物学意义。根据该模型，TR 细胞群的持续存在和扩张严格取决于它们与抗原呈递细胞 (APC) 和传统效应 T (TE) 细胞之间的特定相互作用。这种三伙伴交叉调节迫使 TR 细胞以它们抑制的特定自身免疫活动为食，其影响范围从它们与其他细胞的相互作用到它们在外周和胸腺中的库选择，以及这些细胞与先天免疫系统之间的关系。这些含义源于这样的基本预测：外周动力学将 CD4+ T 细胞库分为两个子集：一组不太多样化的自身反应性效应细胞和调节细胞的小克隆，它们相互调节生长；以及一组更加多样化的几乎没有自身反应性的 TE 细胞克隆，其扩展仅受 APC 可用性的限制。有人认为，这种对曲目的划分为自我与非自我歧视奠定了基础。
Summary: Regulatory CD4+ T cells, enriched in the CD25 pool of healthy individuals, mediate natural tolerance and prevent autoimmune diseases. Despite their fundamental and potential clinical significance, regulatory T (TR) cells have not yet been incorporated in a coherent theory of the immune system. This article reviews experimental evidence and theoretical arguments supporting a model of TR cell dynamics, uncovering some of its most relevant biological implications. According to this model, the persistence and expansion of TR cell populations depend strictly on specific interactions they make with antigen‐presenting cells (APCs) and conventional effector T (TE) cells. This three‐partner crossregulation imposes that TR cells feed on the specific autoimmune activities they suppress, with implications ranging from their interactions with other cells to their repertoire selection in the periphery and in the thymus, and to the relationship between these cells and the innate immune system. These implications stem from the basic prediction that the peripheral dynamics sort the CD4+ T‐cell repertoire into two subsets: a less diverse set of small clones of autoreactive effector and regulatory cells that regulate each other’s growth, and a more diverse set of barely autoreactive TE cell clones, whose expansion is limited only by APC availability. It is argued that such partitioning of the repertoire sets the ground for self–non‐self discrimination.
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影响因子：
12.8
作者：
Panoutsakopoulou, V;Cantor, H
通讯作者：
Cantor, H
DOI：
10.1016/0167-5699(92)90198-g
发表时间：
1992-01-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
JANEWAY, CA
通讯作者：
JANEWAY, CA
DOI：
10.1073/pnas.0501701102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Wan, YSY;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
32.4
作者：
WILLERFORD, DM;CHEN, JZ;ALT, FW
通讯作者：
ALT, FW
影响因子：
32.4
作者：
Malek, TR;Yu, AX;Kong, L
通讯作者：
Kong, L