Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus.
Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus.
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DOI：
10.1111/ppe.12182
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发表时间：
2015-05
影响因子：
2.8
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Arnold DL;Enquobahrie DA;Qiu C;Huang J;Grote N;VanderStoep A;Williams MA
虽然维生素D缺乏与2型糖尿病的相关性已经得到很好的证明，但关于维生素D和妊娠期糖尿病(GDM)风险的研究报告了不一致的结果。我们研究了维生素D状况与妊娠期糖尿病的关系。在一项嵌套式病例队列研究中(135例妊娠期糖尿病患者和517例非妊娠期糖尿病对照)，我们在妊娠早期(平均16周)用液相色谱-串联质谱仪测定了母体血清维生素D状态(总计25[OH]D和25[OH]D3)。妊娠期糖尿病的诊断依据ADA指南。我们使用Logistic回归模型计算调整后的优势比(OR)和95%的可信区间(CI)。妊娠期糖尿病患者的25[OH]D总量(27.3 ng/ml比29.3 ng/ml)和25[OH]D3(23.9 ng/ml比26.7 ng/ml)的平均浓度低于非妊娠期糖尿病患者(均P<0.05)。总体而言，25[OH]D3浓度，而不是总的25[OH]D浓度，与妊娠期糖尿病的风险显著相关。25[OH]D3浓度增加5 ng/ml与GDM风险降低14%相关(P值=0.02)。25[OH]D3浓度最低四分位数的女性患妊娠期糖尿病的风险是最高四分位数女性的两倍(95%可信区间1.15-3.58)(Trend<；0.05的P值)。妊娠早期维生素D的状况，特别是25[OH]D3，与妊娠期糖尿病的风险呈负相关。
While associations of vitamin D deficiency with Type 2 diabetes have been well demonstrated, investigations of vitamin D and risk of gestational diabetes mellitus (GDM) reported inconsistent findings. We examined associations of vitamin D status with GDM. In a nested case-cohort study (135 GDM cases and 517 non-GDM controls), we measured maternal serum Vit-D status (total 25[OH]D and 25[OH]D3) in early pregnancy (16 weeks on average) using liquid chromatography-tandem mass spectroscopy. GDM was diagnosed according to the ADA guidelines. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CI) using logistic regression models. GDM cases had lower mean total 25[OH]D (27.3 vs. 29.3ng/ml) and 25[OH]D3 (23.9 vs. 26.7ng/ml) concentrations compared with women who did not develop GDM (both P-values<0.05). Overall, 25[OH]D3 concentrations, but not total 25[OH]D concentrations, were significantly associated with GDM risk. A 5ng/ml increase in 25[OH]D3 concentration was associated with a 14% decrease in GDM risk (P-value=0.02). Women in the lowest quartile for 25[OH]D3 concentration had a 2-fold (95%CI 1.15-3.58) higher risk of GDM compared with women in the highest quartile (P-value for trend<0.05). Early pregnancy vitamin D status, particularly 25[OH]D3, is inversely associated with GDM risk.
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影响因子：
7.7
作者：
Duncan, BB;Schmidt, MI;Heiss, G
通讯作者：
Heiss, G
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Ashraf A
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通讯作者：
Pena-Rosas, Juan Pablo
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通讯作者：
GRODSKY, GM
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Aghajafari, Fariba;Nagulesapillai, Tharsiya;Rabi, Doreen M.
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Rabi, Doreen M.