Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis.
Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis.
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DOI：
10.1155/2010/351385
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发表时间：
2010
影响因子：
2.8
通讯作者：
Ashraf A
中科院分区：
文献类型：
--
作者：
Alvarez JA;Ashraf A
维生素D的功能并不局限于对骨骼健康的益处，还可能延伸到保护胰岛素分泌和胰岛素敏感性。本文综述了维生素D对血糖稳态和胰岛素敏感性的潜在影响的文献。横断面数据提供了一些证据，表明循环中的25-羟基维生素D(25(OH)D)与胰岛素抵抗呈负相关，尽管需要直接测量胰岛素敏感性才能证实。然而，已报道的与胰岛素分泌之间的联系是相互矛盾的。现有的前瞻性研究支持高25(OH)D浓度对2型糖尿病风险的保护性影响。维生素D干预对胰岛素分泌和敏感性的结果普遍缺乏一致性，这可能是由于受试者群体、干预时间和维生素D补充形式的差异。维生素D受体基因多态性和维生素D与胰岛素样生长因子系统的相互作用可能进一步影响血糖稳态。最佳维生素D剂量方案和最佳血清25(OH)D治疗浓度的模糊性限制了可用的干预研究。未来的研究，包括横断面和前瞻性研究，应该在维生素D缺乏和2型糖尿病的高危人群中进行。需要精心设计、安慰剂对照的随机干预研究，以确定维生素D对血糖稳态的真正保护性影响。
Vitamin D functions are not limited to skeletal health benefits and may extend to preservation of insulin secretion and insulin sensitivity. This review summarizes the literature related to potential vitamin D influences on glucose homeostasis and insulin sensitivity. Cross-sectional data provide some evidence that circulating 25-hydroxyvitamin D (25(OH)D) is inversely associated with insulin resistance, although direct measurements of insulin sensitivity are required for confirmation. Reported associations with insulin secretion, however, are contradictory. Available prospective studies support a protective influence of high 25(OH)D concentrations on type 2 diabetes mellitus risk. There is a general lack of consistency in vitamin D intervention outcomes on insulin secretion and sensitivity, likely due to differences in subject populations, length of interventions, and forms of vitamin D supplementation. Vitamin D receptor gene polymorphisms and vitamin D interactions with the insulin like growth factor system may further influence glucose homeostasis. The ambiguity of optimal vitamin D dosing regimens and optimal therapeutic concentrations of serum 25(OH)D limit available intervention studies. Future studies, including cross-sectional and prospective, should be performed in populations at high risk for both vitamin D deficiency and type 2 diabetes mellitus. Well-designed, placebo-controlled, randomized intervention studies are required to establish a true protective influence of vitamin D on glucose homeostasis.
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