Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice.
Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice.
复制标题
DOI：
10.1038/s41598-018-28034-4
复制
发表时间：
2018-06-25
影响因子：
4.6
通讯作者：
Shibuki K
中科院分区：
文献类型：
--
作者：
Yamagishi T;Yoshitake K;Kamatani D;Watanabe K;Tsukano H;Hishida R;Takahashi K;Takahashi S;Horii A;Yagi T;Shibuki K
粘附原钙粘素（Pcdhs）是一种神经细胞粘附分子，在小鼠体内由58种不同的同种型组成，其四聚体之间具有嗜同性粘附作用。Pcdhs的多样性和由此产生的高度特异性神经元粘附可能是形成执行更高脑功能的神经回路所必需的。然而，这一假设仍有待验证，因为敲除Pcdh基因会产生可能间接干扰高级脑功能的异常。在Pcdh-α 1，12小鼠中，14种异构体中只有α1、α12和两种组成型异构体表达。Pcdh-α 1，12小鼠的外观和行为与野生型小鼠相似，Pcdh-α敲除小鼠中报告的大多数异常在Pcdh-α 1，12小鼠中不存在。我们详细检查了Pcdh-α 1，12小鼠，发现视觉皮层中视觉和触须感觉之间的感觉失配引起的皮层抑制受损。由于Pcdh-α密集分布于大脑皮层，因此Pcdh-α 1，12小鼠中可能存在各种类型的高级功能受损。正如预期的那样，在使用空间/形状线索的行为实验中，空间/形状的视觉短期记忆受损。此外，基于视听联想记忆的行为学习也受到损害。这些结果表明Pcdh-α的分子多样性对感觉整合和短期记忆起着至关重要的作用。
Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by homophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mice, only α1, α12 and two constitutive isoforms are expressed out of 14 isoforms. The appearance and behavior of Pcdh-α1,12 mice are similar to those of wild-type mice, and most abnormalities reported in Pcdh-α knockout mice are not present in Pcdh-α1,12 mice. We examined Pcdh-α1,12 mice in detail, and found that cortical depression induced by sensory mismatches between vision and whisker sensation in the visual cortex was impaired. Since Pcdh-α is densely distributed over the cerebral cortex, various types of higher function are likely impaired in Pcdh-α1,12 mice. As expected, visual short-term memory of space/shape was impaired in behavioral experiments using space/shape cues. Furthermore, behavioral learning based on audio-visual associative memory was also impaired. These results indicate that the molecular diversity of Pcdh-α plays essential roles for sensory integration and short-term memory.
登录
查看更多内容
影响因子：
4.8
作者：
Hasegawa S;Kumagai M;Hagihara M;Nishimaru H;Hirano K;Kaneko R;Okayama A;Hirayama T;Sanbo M;Hirabayashi M;Watanabe M;Hirabayashi T;Yagi T
通讯作者：
Yagi T
小鼠轴突平铺和血清素能电路的组装需要 Pcdh alpha c2
DOI：
10.1126/science.aal3231
发表时间：
2017-04-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Chen WV;Nwakeze CL;Denny CA;O'Keeffe S;Rieger MA;Mountoufaris G;Kirner A;Dougherty JD;Hen R;Wu Q;Maniatis T
通讯作者：
Maniatis T
影响因子：
7.7
作者：
Matias, Sara;Lottem, Eran;Mainen, Zachary F.
通讯作者：
Mainen, Zachary F.
影响因子：
3.5
作者：
Hasegawa, Sonoko;Hamada, Shun;Yagi, Takeshi
通讯作者：
Yagi, Takeshi
影响因子：
5.3
作者：
Katori, Shota;Hamada, Shun;Yagi, Takeshi
通讯作者：
Yagi, Takeshi