Exploring the elusive composition of corpora amylacea of human brain.
Exploring the elusive composition of corpora amylacea of human brain.
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DOI：
10.1038/s41598-018-31766-y
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发表时间：
2018-09-10
影响因子：
4.6
通讯作者：
Vilaplana J
中科院分区：
文献类型：
--
作者：
Augé E;Duran J;Guinovart JJ;Pelegrí C;Vilaplana J
淀粉体（CA）是在衰老过程中积累在人脑中的葡聚糖体，也大量存在于神经退行性疾病中。关于CA功能的理论随着新组件的描述而定期更新。在以前的工作中，我们揭示了CA中存在一些新表位，以及存在一些针对这些新表位的天然IgM抗体。我们还注意到，这些新表位和IgM是CA免疫组织化学研究中假染色的原因，并反驳了其中存在β-淀粉样肽和tau蛋白的假设。在这里，我们扩展了错误归因于CA的组件列表。我们发现，与以前的描述相反，CA不包含GFAP，S100，AQP 4，NeuN或III类β-微管蛋白，我们质疑其他成分的存在。尽管如此，我们观察到，CA含有泛素和p62，它们都与废物的消除过程，以及糖原合成酶，一种必不可少的酶的聚葡聚糖的形成。总之，这项研究表明，有必要继续审查以前的研究CA，但更重要的是，它表明，CA作为结构参与保护或清洁机制的愿景仍然是最一致的理论。
Corpora amylacea (CA) are polyglucosan bodies that accumulate in the human brain during ageing and are also present in large numbers in neurodegenerative conditions. Theories regarding the function of CA are regularly updated as new components are described. In previous work, we revealed the presence of some neo-epitopes in CA and the existence of some natural IgM antibodies directed against these neo-epitopes. We also noted that these neo-epitopes and IgMs were the cause of false staining in CA immunohistochemical studies, and disproved the proposed presence of β-amyloid peptides and tau protein in them. Here we extend the list of components erroneously attributed to CA. We show that, contrary to previous descriptions, CA do not contain GFAP, S100, AQP4, NeuN or class III β-tubulin, and we question the presence of other components. Nonetheless, we observe that CA contains ubiquitin and p62, both of them associated with processes of elimination of waste substances, and also glycogen synthase, an indispensable enzyme for polyglucosan formation. In summary, this study shows that it is imperative to continue reviewing previous studies about CA but, more importantly, it shows that the vision of CA as structures involved in protective or cleaning mechanisms remains the most consistent theory.
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影响因子：
7.9
作者：
Manich, Gemma;Auge, Elisabet;Pelegri, Carme
通讯作者：
Pelegri, Carme
影响因子：
3.7
作者：
Day RJ;Mason MJ;Thomas C;Poon WW;Rohn TT
通讯作者：
Rohn TT
影响因子：
6.2
作者：
Augé E;Pelegrí C;Manich G;Cabezón I;Guinovart JJ;Duran J;Vilaplana J
通讯作者：
Vilaplana J
影响因子：
2.9
作者：
Hoyaux, D;Decaestecker, C;Pochet, R
通讯作者：
Pochet, R
DOI：
10.1016/s0169-328x(01)00166-8
发表时间：
2001-10-19
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Buervenich, S;Olson, L;Galter, D
通讯作者：
Galter, D