Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group.
Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group.
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DOI：
10.1038/s41398-021-01382-y
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发表时间：
2021-05-06
影响因子：
6.8
通讯作者：
Lorenzetti V
中科院分区：
文献类型：
--
作者：
Rossetti MG;Mackey S;Patalay P;Allen NB;Batalla A;Bellani M;Chye Y;Conrod P;Cousijn J;Garavan H;Goudriaan AE;Hester R;Martin-Santos R;Solowij N;Suo C;Thompson PM;Yücel M;Brambilla P;Lorenzetti V
男性和女性表现出不同的大麻使用模式和相关的心理社会后果。然而，这种差异背后的神经解剖学基础知之甚少。本研究的目的是绘制依赖性和娱乐性大麻使用的神经生物学（以大脑体积为指标）的性别差异。我们比较了先验感兴趣区域的体积（即，杏仁核，海马，丘脑，丘脑，眶额皮质（OFC），前扣带皮质和小脑）之间的129定期大麻用户（其中70人是娱乐用户和59大麻依赖）和114名对照组从ENIGMA成瘾工作组招募，占颅内体积，年龄，智商，酒精和烟草的使用。依赖大麻的用户，特别是女性，有（轻微显着）较小的体积的横向OFC和小脑白色问题比娱乐用户和控制。在依赖性（但不是娱乐性）大麻使用者中，女性与小脑白色物质和OFC体积较小之间存在显着关联。OFC的数量也预测了每月标准的饮料。其他感兴趣的大脑区域没有出现显著的影响。我们的研究结果保证了未来的多模式研究，研究性别和大麻依赖是否是大麻使用者神经生物学改变的特定关键驱动因素。反过来，这可能有助于确定特别涉及脆弱大麻使用者的神经通路（例如，对大麻有依赖的女性），并为治疗提供个性化的神经生物学目标。
Males and females show different patterns of cannabis use and related psychosocial outcomes. However, the neuroanatomical substrates underlying such differences are poorly understood. The aim of this study was to map sex differences in the neurobiology (as indexed by brain volumes) of dependent and recreational cannabis use. We compared the volume of a priori regions of interest (i.e., amygdala, hippocampus, nucleus accumbens, insula, orbitofrontal cortex (OFC), anterior cingulate cortex and cerebellum) between 129 regular cannabis users (of whom 70 were recreational users and 59 cannabis dependent) and 114 controls recruited from the ENIGMA Addiction Working Group, accounting for intracranial volume, age, IQ, and alcohol and tobacco use. Dependent cannabis users, particularly females, had (marginally significant) smaller volumes of the lateral OFC and cerebellar white matter than recreational users and controls. In dependent (but not recreational) cannabis users, there was a significant association between female sex and smaller volumes of the cerebellar white matter and OFC. Volume of the OFC was also predicted by monthly standard drinks. No significant effects emerged the other brain regions of interest. Our findings warrant future multimodal studies that examine if sex and cannabis dependence are specific key drivers of neurobiological alterations in cannabis users. This, in turn, could help to identify neural pathways specifically involved in vulnerable cannabis users (e.g., females with cannabis dependence) and inform individually tailored neurobiological targets for treatment.
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影响因子：
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