The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown.
The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown.
复制标题
免疫细胞在中风后血管生成和神经元重塑中的作用：已知和未知。
DOI：
10.3389/fimmu.2021.784098
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Ma Y;Yang S;He Q;Zhang D;Chang J
脑缺血事件发生后，由于脑缺血引起的脑病理，细胞和分子活动都会发生实质性的变化。越来越多的证据表明，免疫细胞的强健募集在中风急性期起着核心作用。渗入的外周免疫细胞和驻留的小胶质细胞通过释放炎症相关分子来调节神经细胞死亡和血脑屏障的破坏。然而，在中风的亚急性和慢性恢复期背景下，深刻的免疫学效应几乎没有受到关注。在实验性中风研究中，早期试图抑制免疫细胞渗透在减轻脑损伤方面是有效的，但在临床试验中未能发挥有益的效果。神经组织损伤修复过程包括血管生成、神经再生和突触重塑等。卒中后炎症细胞可以采取不同的表型，通过减轻急性炎症反应或分泌多种生长因子来影响内皮细胞和神经干细胞的上述生物学过程，这些生长因子在血管生成和神经再生过程中发挥重要作用。为了更好地了解免疫细胞在卒中后神经组织修复过程中的多种作用，我们对免疫细胞在血管生成、神经发生和神经元重塑中的作用进行了综述。对这些炎症机制的全面了解可能有助于确定开发新的免疫调节治疗策略的潜在靶点，以改善中风后的并发症和功能康复。
Following a cerebral ischemic event, substantial alterations in both cellular and molecular activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates that the robust recruitment of immune cells plays a central role in the acute stage of stroke. Infiltrating peripheral immune cells and resident microglia mediate neuronal cell death and blood-brain barrier disruption by releasing inflammation-associated molecules. Nevertheless, profound immunological effects in the context of the subacute and chronic recovery phase of stroke have received little attention. Early attempts to curtail the infiltration of immune cells were effective in mitigating brain injury in experimental stroke studies but failed to exert beneficial effects in clinical trials. Neural tissue damage repair processes include angiogenesis, neurogenesis, and synaptic remodeling, etc. Post-stroke inflammatory cells can adopt divergent phenotypes that influence the aforementioned biological processes in both endothelial and neural stem cells by either alleviating acute inflammatory responses or secreting a variety of growth factors, which are substantially involved in the process of angiogenesis and neurogenesis. To better understand the multiple roles of immune cells in neural tissue repair processes post stroke, we review what is known and unknown regarding the role of immune cells in angiogenesis, neurogenesis, and neuronal remodeling. A comprehensive understanding of these inflammatory mechanisms may help identify potential targets for the development of novel immunoregulatory therapeutic strategies that ameliorate complications and improve functional rehabilitation after stroke.
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DOI：
10.1073/pnas.0402455101
发表时间：
2004-07-27
影响因子：
11.1
作者：
Corcione, A;Casazza, S;Pistoia, V
通讯作者：
Pistoia, V
影响因子：
5.3
作者：
Carmichael ST;Kathirvelu B;Schweppe CA;Nie EH
通讯作者：
Nie EH
对中性粒细胞的新见解：脑缺血的潜在治疗靶点
影响因子：
7.3
作者：
Chen R;Zhang X;Gu L;Zhu H;Zhong Y;Ye Y;Xiong X;Jian Z
通讯作者：
Jian Z
DOI：
10.1038/s41573-019-0041-4
发表时间：
2019-10
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Ferreira LMR;Muller YD;Bluestone JA;Tang Q
通讯作者：
Tang Q
影响因子：
3.5
作者：
Batchelor, PE;Porritt, MJ;Howells, DW
通讯作者：
Howells, DW