Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD.
Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD.
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DOI：
10.1016/j.resp.2016.09.008
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发表时间：
2017-01
影响因子：
2.3
通讯作者：
Rossiter HB
中科院分区：
文献类型：
--
作者：
Adami A;Cao R;Porszasz J;Casaburi R;Rossiter HB
肌肉氧化能力低是慢性阻塞性肺疾病(COPD)患者运动耐量降低的原因之一。近红外光谱(NIRS)可以无创地测定肌肉耗氧恢复速率常数(K)，它与氧化能力成正比，前提是满足两个条件：1)运动强度足以充分激活线粒体氧化酶；2)足够的氧气供应。我们的目的是确定NIRSk评估的重复性(变异系数，CV；组内相关系数，ICC)在受试者的腓肠肌(预计FEV1FEV1±23%预测)和非COPD参与者(FEV19FEV1预测FEV198±14%)。10-15s动态收缩先于间歇性动脉闭塞6min(每次5-10s，~250 mm Hg)测量k。慢性阻塞性肺疾病患者K值(1.43±0.4min−_1；CV=9.8±5.9%，ICc=0.88)明显低于对照组(1.74±0.69min−_1；CV=9.9±8.4%；ICc=0.93)。当收缩后和去氧量较低时，K重复性较差，提示运动强度不足，线粒体激活和/或NIRS信号不包含来自活跃肌肉的光。NIRS评估对COPD患者的肌肉功能障碍评估具有良好的耐受性和重复性。
Low muscle oxidative capacity contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Near-infrared spectroscopy (NIRS) allows non-invasive determination of the muscle oxygen consumption recovery rate constant (k), which is proportional to oxidative capacity assuming two conditions are met: 1) exercise intensity is sufficient to fully-activate mitochondrial oxidative enzymes; 2) sufficient O2 availability. We aimed to determine reproducibility (coefficient of variation, CV; intraclass correlation coefficient, ICC) of NIRS k assessment in the gastrocnemius of 64 participants with (FEV1 64±23%predicted) or without COPD (FEV1 98±14%predicted). 10–15s dynamic contractions preceded 6min of intermittent arterial occlusions (5–10s each, ~250mmHg) for k measurement. k was lower (P<0.05) in COPD (1.43±0.4min−1; CV=9.8±5.9%, ICC=0.88) than controls (1.74±0.69min−1; CV=9.9±8.4%; ICC=0.93). Poor k reproducibility was more common when post-contraction and deoxygenation were low, suggesting insufficient exercise intensity for mitochondrial activation and/or the NIRS signal contained little light reflected from active muscle. The NIRS assessment was well tolerated and reproducible for muscle dysfunction evaluation in COPD.
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影响因子：
3
作者：
Erickson, Melissa Lynn;Ryan, Terence E.;Young, Hui-Ju;McCully, Kevin K.
通讯作者：
McCully, Kevin K.
DOI：
10.1097/00005768-200107001-00004
发表时间：
2001-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Casaburi, R
通讯作者：
Casaburi, R
DOI：
10.1164/ajrccm.154.2.8756820
发表时间：
1996-08-01
影响因子：
24.7
作者：
Maltais, F;LeBlanc, P;Belleau, R
通讯作者：
Belleau, R
影响因子：
3.3
作者：
MCCULLY, KK;IOTTI, S;CHANCE, B
通讯作者：
CHANCE, B
影响因子：
24.3
作者：
Coronell, C;Orozco-Levi, M;Gea, J
通讯作者：
Gea, J