Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas.
Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas.
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DOI：
10.1016/j.jtho.2019.07.008
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Adusumilli PS
中科院分区：
文献类型：
--
作者：
Emoto K;Eguchi T;Tan KS;Takahashi Y;Aly RG;Rekhtman N;Travis WD;Adusumilli PS
典型的微乳头(MIP)模式在2015年WHO分类中定义为肿瘤细胞生长在乳头状簇中，形成小花，缺乏纤维血管核心，与预后不良有关。我们观察到了一种新的模式，我们称之为丝状MIP模式，并研究了它与经典MIP模式的关系。丝状图案被定义为肿瘤细胞生长在精致的花边状狭窄的细胞堆积中，没有纤维血管核心。我们需要至少3个来自肺泡壁基底层的堆积的细胞核，其宽度最大可达3个细胞。为了评估丝状基因与经典MIP模式的关系，我们记录了1468例I期浸润性腺癌的临床和病理特征，包括使用竞争风险的累积复发发生率(CIR)进行生存分析。我们在35%的病例中观察到丝状MIP模式。通过将丝状模式包括为MIP，除了先前诊断的87例MIP为主的腺癌外，我们还识别了57例MIP为主的病例。其中乳头状腺癌37例，腺泡型腺癌16例，实性腺癌4例。在144MIP占优势的腺癌中，丝状占优势的MIP(n=78)与经典占优势的MIP(n=66)一样预后不良(P=0.464)。此外，与经典MIP一样(p=0.010)，在多变量分析中，即使是少量的丝状MIP(≥5%)也与更差的CIR显著相关(p=0.001)。与经典MIP相关的频繁和相似的不良预后支持将丝状模式包括在MIP亚型中。
The classical micropapillary (MIP) pattern is defined in the 2015 WHO classification as tumor cells growing in papillary tufts forming florets that lack fibrovascular cores and it is associated with poor prognosis. We observed a novel pattern that we termed to be a filigree MIP pattern and investigated its relationship to the classical MIP pattern. Filigree pattern was defined as tumor cells growing in delicate lace-like narrow stacks of cells without fibrovascular cores. We required at least 3 piled-up nuclei from the alveolar wall basal layer with a breadth of up to 3 cells across. To assess the relationship of the filigree vs classical MIP pattern, we documented their frequency in the context of clinical and pathologic characteristics of 1468 Stage I invasive adenocarcinomas including survival analysis using cumulative incidence of recurrence (CIR) by competing risks. We observed the filigree MIP pattern in 35% of cases. By including the filigree pattern as MIP, we identified 57 more MIP predominant cases in addition to the previously diagnosed 87 MIP predominant adenocarcinomas. These 57 cases were reclassified from papillary (n=37), acinar (n=16), and solid (n=4) predominant adenocarcinoma, respectively. Of the 144 MIP predominant adenocarcinomas, filigree predominant MIP (n=78) showed a poor prognosis like classical predominant MIP (n=66) (p=0.464). In addition, like classical MIP (p=0.010), even small an amount (≥5%) of filigree MIP was significantly associated with worse CIR (p=0.001) in multivariable analysis. The frequent association with classical MIP and the similar poor prognosis supports inclusion of the filigree pattern in the MIP subtype.
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影响因子：
5.6
作者：
Miyoshi, T;Satoh, Y;Ishikawa, Y
通讯作者：
Ishikawa, Y
影响因子：
0.8
作者：
Hayakawa, Takamitsu;Tajima, Shogo;Tsukui, Masaru;Takanashi, Yusuke;Neyatani, Hiroshi;Funai, Kazuhito
通讯作者：
Funai, Kazuhito
DOI：
10.1016/j.jtho.2018.09.008
发表时间：
2019-01
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Bains S;Eguchi T;Warth A;Yeh YC;Nitadori JI;Woo KM;Chou TY;Dienemann H;Muley T;Nakajima J;Shinozaki-Ushiku A;Wu YC;Lu S;Kadota K;Jones DR;Travis WD;Tan KS;Adusumilli PS
通讯作者：
Adusumilli PS
DOI：
10.1038/modpathol.2012.58
发表时间：
2012-08
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
通讯作者：
--
影响因子：
20.4
作者：
Russell, Prudence A.;Wainer, Zoe;Williams, Richard A.
通讯作者：
Williams, Richard A.