Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER.
Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER.
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DOI：
10.1002/anie.202108306
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发表时间：
2021-09-13
期刊：
影响因子：
--
通讯作者：
Glöggler S
中科院分区：
文献类型：
--
作者：
Korchak S;Kaltschnee L;Dervisoglu R;Andreas L;Griesinger C;Glöggler S
核磁共振通常受到其内在低灵敏度的极大限制：只有几个自旋对整个信号有贡献。为了克服这一限制，超极化方法被开发出来，其使信号增加到正常/热极化信号的数倍。最理想的情况是一种通用的方法，它可以用信号增强溶液中感兴趣的完整样品，以提高检测灵敏度。在这里，我们介绍了对氢增强磁共振与激光现象的结合：对氢增强分子的大信号以一种自发地转换为同相信号的方式与磁共振线圈相互作用。这些分子通过偶极偶联直接与其他化合物相互作用，并增强它们的信号。我们证明这不仅对溶剂分子是可能的，对氨基酸也是可能的。我们介绍了对氢增强磁共振与激光和自发极化转移现象的结合：对氢增强分子的大信号以一种自发转换为同相信号的方式与磁共振线圈相互作用。这些分子通过偶极偶联直接与其他化合物相互作用，并增强它们的信号。
Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity: Only a few spins contribute to the overall signal. To overcome this limitation, hyperpolarization methods were developed that increase signals several times beyond the normal/thermally polarized signals. The ideal case would be a universal approach that can signal enhance the complete sample of interest in solution to increase detection sensitivity. Here, we introduce a combination of para‐hydrogen enhanced magnetic resonance with the phenomenon of the RASER: Large signals of para‐hydrogen enhanced molecules interact with the magnetic resonance coil in a way that the signal is spontaneously converted into an in‐phase signal. These molecules directly interact with other compounds via dipolar couplings and enhance their signal. We demonstrate that this is not only possible for solvent molecules but also for an amino acid. We introduce the combination of para‐hydrogen enhanced magnetic resonance with the phenomenon of the RASER and spontaneous polarization transfer: Large signals of para‐hydrogen enhanced molecules interact with the magnetic resonance coil in a way that the signal is spontaneously converted into an in‐phase signal. These molecules directly interact with other compounds via dipolar couplings and enhance their signal.
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