Computerized cognitive training for children with neurofibromatosis type 1: A pilot resting-state fMRI study.
Computerized cognitive training for children with neurofibromatosis type 1: A pilot resting-state fMRI study.
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DOI：
10.1016/j.pscychresns.2017.06.003
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发表时间：
2017-08-30
期刊：
影响因子：
--
通讯作者：
Acosta MT
中科院分区：
文献类型：
--
作者：
Yoncheva YN;Hardy KK;Lurie DJ;Somandepalli K;Yang L;Vezina G;Kadom N;Packer RJ;Milham MP;Castellanos FX;Acosta MT
在这项初步研究中，我们检测了一个计算机化工作记忆程序对1型神经纤维瘤病（NF1）儿童静息态功能磁共振成像（fMRI）指标的训练效果。我们对比了16名患有NF1且有记录的工作记忆困难的参与者（9名男性；年龄11.1±2.3岁）训练前后的静息态fMRI和认知指标。通过非参数置换检验推断，我们在四个体素层面的静息态指标中的两个发现了显著的区域特异性差异（经家族错误校正）：低频波动幅度分数（反映自发振荡的峰谷强度）和局部一致性（反映局部内在同步性）。同时也观察到一些认知任务的改善。这些初步发现表明，静息态fMRI指标的区域特异性变化可能与NF1中与治疗相关的认知改善有关。然而，在独立对照重复研究之前，当前的结果必须谨慎解读。
In this pilot study, we examined training effects of a computerized working memory program on resting state functional magnetic resonance imaging (fMRI) measures in children with neurofibromatosis type 1 (NF1). We contrasted pre- with post-training resting state fMRI and cognitive measures from 16 participants (nine males; 11.1±2.3 years) with NF1 and documented working memory difficulties. Using non-parametric permutation test inference, we found significant regionally specific differences (family-wise error corrected) in two of four voxel-wise resting state measures: fractional amplitude of low frequency fluctuations (indexing peak-to-trough intensity of spontaneous oscillations) and regional homogeneity (indexing local intrinsic synchrony). Some cognitive task improvement was observed as well. These preliminary findings suggest that regionally specific changes in resting state fMRI indices may be associated with treatment-related cognitive amelioration in NF1. Nevertheless, current results must be interpreted with caution pending independent controlled replication.
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