Strengthening connections: functional connectivity and brain plasticity.
Strengthening connections: functional connectivity and brain plasticity.
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DOI：
10.1007/s11065-014-9252-y
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发表时间：
2014-03
影响因子：
5.8
通讯作者：
Castellanos, F. Xavier
中科院分区：
文献类型：
--
作者：
Kelly, Clare;Castellanos, F. Xavier
功能性神经影像学的优势促进了将基于网络的方法纳入神经心理学家评估脑损伤后遗症的工具箱。特别是，静息态功能磁共振成像（R - fMRI）数据的内在功能连接（iFC）映射是测量人脑中宏观网络的一种理想方法。除了iFC映射在描绘大脑的功能拓扑结构如何因损伤和伤害而改变方面的价值外，iFC分析还能在大规模功能网络的宏观层面深入了解经验依赖性可塑性的影响。这些见解是设计最有利于功能恢复的训练和康复干预措施的基础。在这篇综述中，我们探讨了目前对大脑中iFC的起源和功能的了解，以及这些知识在神经心理学环境中的作用。然后，我们总结了在健康对照参与者中研究经验驱动的iFC可塑性的相关研究，并根据一种可能有助于解释结果和为康复研究生成假设的模式来阐述这些发现。最后，我们概述了R - fMRI方法的一些注意事项，以及一些可能提高iFC范式在神经心理学中实用性的当前进展。
The ascendancy of functional neuroimaging has facilitated the addition of network-based approaches to the neuropsychologist’s toolbox for evaluating the sequelae of brain insult. In particular, intrinsic functional connectivity (iFC) mapping of resting state fMRI (R-fMRI) data constitutes an ideal approach to measuring macro-scale networks in the human brain. Beyond the value of iFC mapping for charting how the functional topography of the brain is altered by insult and injury, iFC analyses can provide insights into effects of experience-dependent plasticity at the macro level of large-scale functional networks. Such insights are foundational to the design of training and remediation interventions that will best facilitate recovery of function. In this review, we consider what is currently known about the origin and function of iFC in the brain, and how this knowledge is informative in neuropsychological settings. We then summarize studies that have examined experience-driven plasticity of iFC in healthy control participants, and frame these findings in terms of a schema that may aid in the interpretation of results and the generation of hypothesis for rehabilitative studies. Finally, we outline some caveats to the R-fMRI approach, as well as some current developments that are likely to bolster the utility of the iFC paradigm for neuropsychology.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
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作者：
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DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
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DOI：
10.1177/1073858409354384
发表时间：
2011-02
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
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作者：
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通讯作者：
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
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