Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study.
Implementing SARS-CoV-2 Rapid Antigen Testing in the Emergency Ward of a Swiss University Hospital: The INCREASE Study.
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DOI：
10.3390/microorganisms9040798
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发表时间：
2021-04-10
期刊：
影响因子：
4.5
通讯作者：
Greub G
中科院分区：
文献类型：
--
作者：
Caruana G;Croxatto A;Kampouri E;Kritikos A;Opota O;Foerster M;Brouillet R;Senn L;Lienhard R;Egli A;Pantaleo G;Carron PN;Greub G
继瑞士联邦公共卫生办公室（FOPH）授权快速抗原检测（RAT）后，我们在大学医院的急诊病房实施了RAT的使用，用于患者分组。 RAT 分类与 RT-PCR 结合使我们能够及时隔离阳性患者并节省资源。在 532 名患者中，Exdia 的总体敏感性为 48.3%，Standard Q®、PanbioTM 和 BD Veritor™ 的总体敏感性为 41.2%。所有 RAT 的特异性均高于 99%。对于病毒载量高于 105 拷贝/mL，Exdia、Standard Q®、PanbioTM 和 BD Veritor™ 的灵敏度分别提高到 74.6%、66.2%、66.2% 和 64.8%，对于病毒载量高于 106 拷贝/mL 的灵敏度分别提高到 100%、97.8%、96.6% 和 95.6%，对于高于 106 拷贝/mL 的病毒载量，灵敏度分别提高到 100% 107 拷贝/mL。四天内出现症状的患者（分别为 74.3%、69.2%、69.2% 和 64%）的敏感性显着高于症状演变超过四天的患者（分别为 36.8%、21.1%、21.1% 和 23.7%）。在 COVID-19 无症状患者中，敏感性为 33%。所有免疫球蛋白 A 阳性患者的 RAT 检测结果均为阴性。 RAT 可能是选定临床环境中的有用资源，作为 RT-PCR 中用于快速患者分类的补充工具，但必须考虑到较低的敏感性，特别是在晚期就诊者和 COVID-19 无症状受试者中。
Following the Swiss Federal Office of Public Health (FOPH) authorization of the rapid antigen test (RAT), we implemented the use of the RAT in the emergency ward of our university hospital for patients’ cohorting. RAT triaging in association with RT-PCR allowed us to promptly isolate positive patients and save resources. Among 532 patients, overall sensitivities were 48.3% for Exdia and 41.2% for Standard Q®, PanbioTM and BD Veritor™. All RATs exhibited specificity above 99%. Sensitivity increased to 74.6%, 66.2%, 66.2% and 64.8% for Exdia, Standard Q®, PanbioTM and BD Veritor™, respectively, for viral loads above 105 copies/mL, to 100%, 97.8%, 96.6% and 95.6% for viral loads above 106 copies/mL and 100% for viral loads above 107 copies/mL. Sensitivity was significantly higher for patients with symptoms onset within four days (74.3%, 69.2%, 69.2% and 64%, respectively) versus patients with the evolution of symptoms longer than four days (36.8%, 21.1%, 21.1% and 23.7%, respectively). Among COVID-19 asymptomatic patients, sensitivity was 33%. All Immunoglobulin-A-positive patients resulted negative for RAT. The RAT might represent a useful resource in selected clinical settings as a complementary tool in RT-PCR for rapid patient triaging, but the lower sensitivity, especially in late presenters and COVID-19 asymptomatic subjects, must be taken into account.
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影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
4.5
作者：
Caruana G;Croxatto A;Kampouri E;Kritikos A;Opota O;Foerster M;Brouillet R;Senn L;Lienhard R;Egli A;Pantaleo G;Carron PN;Greub G
通讯作者：
Greub G
影响因子：
5.4
作者：
Osterman A;Baldauf HM;Eletreby M;Wettengel JM;Afridi SQ;Fuchs T;Holzmann E;Maier A;Döring J;Grzimek-Koschewa N;Muenchhoff M;Protzer U;Kaderali L;Keppler OT
通讯作者：
Keppler OT
影响因子：
5.8
作者：
Jacot, Damien;Greub, Gilbert;Opota, Onya
通讯作者：
Opota, Onya
DOI：
10.1016/j.scitotenv.2021.147483
发表时间：
2021-09-15
期刊：
The Science of the total environment
影响因子：
--
作者：
Ladoy A;Opota O;Carron PN;Guessous I;Vuilleumier S;Joost S;Greub G
通讯作者：
Greub G