Mechanism-Based Disease Progression Model Describing Host-Pathogen Interactions During the Pathogenesis of Acinetobacter baumannii Pneumonia.
Mechanism-Based Disease Progression Model Describing Host-Pathogen Interactions During the Pathogenesis of Acinetobacter baumannii Pneumonia.
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DOI：
10.1002/psp4.12312
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Rao GG
中科院分区：
文献类型：
--
作者：
Diep JK;Russo TA;Rao GG
The emergence of highly resistant bacteria is a serious threat to global public health. The host immune response is vital for clearing bacteria from the infected host; however, the current drug development paradigm does not take host‐pathogen interactions into consideration. Here, we used a systems‐based approach to develop a quantitative, mechanism‐based disease progression model to describe bacterial dynamics, host immune response, and lung injury in an immunocompetent rat pneumonia model. Previously, Long‐Evans rats were infected with Acinetobacter baumannii (A. baumannii) strain 307‐0294 at five different inocula and total lung bacteria, interleukin‐1beta (IL‐1β), tumor necrosis factor‐α (TNF‐α), cytokine‐induced neutrophil chemoattractant 1 (CINC‐1), neutrophil counts, and albumin were quantified. Model development was conducted in ADAPT5 version 5.0.54 using a pooled approach with maximum likelihood estimation; all data were co‐modeled. The final model characterized host‐pathogen interactions during the natural time course of bacterial pneumonia. Parameters were estimated with good precision. Our expandable model will integrate drug effects to aid in the design of optimized antibiotic regimens.
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影响因子：
1.7
作者：
Knight, PR;Davidson, BA;Holm, BA
通讯作者：
Holm, BA
DOI：
10.1146/annurev-pathol-020712-164023
发表时间：
2014
期刊：
Annual review of pathology
影响因子：
--
作者：
Mayadas TN;Cullere X;Lowell CA
通讯作者：
Lowell CA
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3.8
作者：
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通讯作者：
Jusko, William J.
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2
作者：
Mochan, Ericka;Swigon, David;Ermentrout, G. Bard;Lukens, Sarah;Clermont, Gilles
通讯作者：
Clermont, Gilles
DOI：
10.1165/rcmb.2009-0210st
发表时间：
2011-05-01
影响因子：
6.4
作者：
Matute-Bello, Gustavo;Downey, Gregory;Villar, Jesus
通讯作者：
Villar, Jesus