Comparison of the Outcomes of Individuals With Medically Attended Influenza A and B Virus Infections Enrolled in 2 International Cohort Studies Over a 6-Year Period: 2009-2015.
Comparison of the Outcomes of Individuals With Medically Attended Influenza A and B Virus Infections Enrolled in 2 International Cohort Studies Over a 6-Year Period: 2009-2015.
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DOI：
10.1093/ofid/ofx212
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发表时间：
2017
影响因子：
4.2
通讯作者：
INSIGHT Influenza Study Group
中科院分区：
文献类型：
--
作者：
Dwyer DE;Lynfield R;Losso MH;Davey RT;Cozzi-Lepri A;Wentworth D;Uyeki TM;Gordin F;Angus B;Qvist T;Emery S;Lundgren J;Neaton JD;INSIGHT Influenza Study Group
比较不同流感病毒类型/亚型感染的前瞻性随访研究的结局数据有限。在2009年至2015年在全球招募的2个前瞻性队列中，比较了实验室确诊的甲型H1N1流感pdm 09、甲型H3 N2流感或B流感病毒感染成人的人口统计学、临床特征和随访结局。使用逻辑回归比较流感病毒类型/亚型之间的结局。在3952例门诊患者中，1290例（32.6%）为A（H1N1）pdm 09病毒感染，1857例（47.0%）为A（H3 N2），805例（20.4%）为B型流感。在1398例住院患者中，641例（45.8%）患有A（H1N1）pdm 09，532例（38.1%）患有A（H3 N2），225例（16.1%）患有B型流感。A（H1N1）pdm 09的门诊患者更年轻，合并症更少，并且在14天的随访期间（3.3%）比流感B（2.2%）或A（H3 N2）（0.7%; P <0.0001）更可能住院。A（H1N1）pdm 09（20.3%）的住院患者比A（H3 N2）（11.3%）或B（9.8%; P <0.0001）的患者更有可能从重症监护室（ICU）招募。然而，出院住院患者的60天随访显示，不同流感类型/亚型之间的疾病进展（P = 0.32）或全因死亡率（P = 0.30）无差异。在协变量调整后，在敏感性分析中，以及按年龄、入组地点和合并症定义的亚组中，这些结果是一致的。感染甲型H1N1流感pdm 09或B型流感的门诊患者比感染甲型H3 N2流感的患者更容易住院。感染A（H1N1）pdm 09的住院患者更年轻，在进入研究时更有可能患有严重疾病（通过ICU登记来衡量），但60天的结果并不差。
Outcome data from prospective follow-up studies comparing infections with different influenza virus types/subtypes are limited. Demographic, clinical characteristics and follow-up outcomes for adults with laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2), or B virus infections were compared in 2 prospective cohorts enrolled globally from 2009 through 2015. Logistic regression was used to compare outcomes among influenza virus type/subtypes. Of 3952 outpatients, 1290 (32.6%) had A(H1N1)pdm09 virus infection, 1857 (47.0%) had A(H3N2), and 805 (20.4%) had influenza B. Of 1398 inpatients, 641 (45.8%) had A(H1N1)pdm09, 532 (38.1%) had A(H3N2), and 225 (16.1%) had influenza B. Outpatients with A(H1N1)pdm09 were younger with fewer comorbidities and were more likely to be hospitalized during the 14-day follow-up (3.3%) than influenza B (2.2%) or A(H3N2) (0.7%; P < .0001). Hospitalized patients with A(H1N1)pdm09 (20.3%) were more likely to be enrolled from intensive care units (ICUs) than those with A(H3N2) (11.3%) or B (9.8%; P < .0001). However, 60-day follow-up of discharged inpatients showed no difference in disease progression (P = .32) or all-cause mortality (P = .30) among influenza types/subtypes. These findings were consistent after covariate adjustment, in sensitivity analyses, and for subgroups defined by age, enrollment location, and comorbidities. Outpatients infected with influenza A(H1N1)pdm09 or influenza B were more likely to be hospitalized than those with A(H3N2). Hospitalized patients infected with A(H1N1)pdm09 were younger and more likely to have severe disease at study entry (measured by ICU enrollment), but did not have worse 60-day outcomes.
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影响因子：
5.5
作者：
Dwyer, Dominic E.
通讯作者：
Dwyer, Dominic E.
影响因子：
64.8
作者：
Neumann, Gabriele;Noda, Takeshi;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
影响因子：
8.8
作者：
Loubet, Paul;Samih-Lenzi, Nezha;Launay, Odile
通讯作者：
Launay, Odile
DOI：
10.1136/bmj.f5061
发表时间：
2013-08-23
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Mertz D;Kim TH;Johnstone J;Lam PP;Science M;Kuster SP;Fadel SA;Tran D;Fernandez E;Bhatnagar N;Loeb M
通讯作者：
Loeb M
影响因子：
10
作者：
Lee, N.;Choi, K. W.;Sung, J. J. Y.
通讯作者：
Sung, J. J. Y.