Association of PER2 genotype and stressful life events with alcohol drinking in young adults.
Association of PER2 genotype and stressful life events with alcohol drinking in young adults.
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DOI：
10.1371/journal.pone.0059136
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Laucht M
中科院分区：
文献类型：
--
作者：
Blomeyer D;Buchmann AF;Lascorz J;Zimmermann US;Esser G;Desrivieres S;Schmidt MH;Banaschewski T;Schumann G;Laucht M
时钟基因控制昼夜节律并影响饮酒对生理系统的影响。经历严重的负面生活事件与酗酒和昼夜节律紊乱有关。本研究的目的是 1) 扩展先前的研究结果，表明 PER2 基因的单倍型标记单核苷酸多态性与饮酒模式之间存在关联，2) 检验该基因与危险饮酒中的生活压力相互作用的可能作用。收集数据作为流行病学队列研究的一部分，研究自出生以来早期危险因素的结果。在 19 岁时，对 268 名年轻人（126 名男性，142 名女性）进行了 PER2 rs56013859 基因分型，并进行了 45 天的酒精时间线随访和酒精使用障碍识别测试 (AUDIT)。生活压力的评估是在过去四年中通过问卷报告并通过访谈验证的严重负面生活事件的数量。研究发现，与主要 A 等位基因纯合子相比，带有 rs56013859 次要 G 等位基因的个体饮酒较少，仅 72% 的天饮酒。此外，在经常饮酒的人中，出现了基因与环境的相互作用（p = .020）。虽然在低压力条件下没有出现基因型的影响，但当暴露于高压力时，G等位基因携带者比A等位基因纯合子携带者表现出更少的危险饮酒。这些发现可能表明昼夜节律基因 PER2 在年轻人的饮酒模式和缓解严重生活压力对有经验的饮酒者危险饮酒的影响方面发挥着作用。然而，考虑到多重测试可能带来的负担、所使用措施的性质以及相互作用的名义证据，在得出明确的结论之前需要进行复制。
Clock genes govern circadian rhythms and shape the effect of alcohol use on the physiological system. Exposure to severe negative life events is related to both heavy drinking and disturbed circadian rhythmicity. The aim of this study was 1) to extend previous findings suggesting an association of a haplotype tagging single nucleotide polymorphism of PER2 gene with drinking patterns, and 2) to examine a possible role for an interaction of this gene with life stress in hazardous drinking. Data were collected as part of an epidemiological cohort study on the outcome of early risk factors followed since birth. At age 19 years, 268 young adults (126 males, 142 females) were genotyped for PER2 rs56013859 and were administered a 45-day alcohol timeline follow-back interview and the Alcohol Use Disorders Identification Test (AUDIT). Life stress was assessed as the number of severe negative life events during the past four years reported in a questionnaire and validated by interview. Individuals with the minor G allele of rs56013859 were found to be less engaged in alcohol use, drinking at only 72% of the days compared to homozygotes for the major A allele. Moreover, among regular drinkers, a gene x environment interaction emerged (p = .020). While no effects of genotype appeared under conditions of low stress, carriers of the G allele exhibited less hazardous drinking than those homozygous for the A allele when exposed to high stress. These findings may suggest a role of the circadian rhythm gene PER2 in both the drinking patterns of young adults and in moderating the impact of severe life stress on hazardous drinking in experienced alcohol users. However, in light of the likely burden of multiple tests, the nature of the measures used and the nominal evidence of interaction, replication is needed before drawing firm conclusions.
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DOI：
10.15288/jsa.2002.63.486
发表时间：
2002-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Park, CL;Levenson, MR
通讯作者：
Levenson, MR
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影响因子：
3.7
作者：
Gamble KL;Motsinger-Reif AA;Hida A;Borsetti HM;Servick SV;Ciarleglio CM;Robbins S;Hicks J;Carver K;Hamilton N;Wells N;Summar ML;McMahon DG;Johnson CH
通讯作者：
Johnson CH
影响因子：
--
作者：
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通讯作者：
Rietschel, Marcella
DOI：
10.1111/j.1469-7610.1997.tb01602.x
发表时间：
1997-10-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
Schumann, Gunter