Interactivity and reward-related neural activation during a serious videogame.
Interactivity and reward-related neural activation during a serious videogame.
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DOI：
10.1371/journal.pone.0033909
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Knutson B
中科院分区：
文献类型：
--
作者：
Cole SW;Yoo DJ;Knutson B
本研究试图确定玩一个“严肃的”互动数字游戏（IDG）--癌症患者的再使命视频游戏--是否激活了与激励动机相关的中脑边缘神经回路，如果是这样，这种影响是否源于互动游戏的参与性方面，或者来自其动态事件流产生的复杂的感官/感知参与。健康的大学生被随机分为两组，在这些组中，他们要么主动玩Re-Mission，要么被动地观察由一组受试者产生的游戏视听流，然后用功能性磁共振成像（FMRI）进行扫描。互动游戏的开始强烈激活了中脑边缘投射区，包括尾状核和中脑核，以及海马旁回的一个亚区。在互动游戏过程中，受试者表现出丘脑、前额叶、壳核和运动相关区域的延长激活，伴随着顶叶和内侧前额叶皮层的激活减少。互动游戏的偏移激活了前扣带回和前扣带回。组间比较受试者内的对比证实，主动游戏组比被动暴露对照组的中脑边缘激活明显更明显。个体差异分析还发现，游戏开始后海马旁激活的程度与扫描结束时和一个月的随访时评估的对化疗的积极态度相关。这些研究结果表明，IDG诱导的奖励相关的中脑边缘神经回路的激活主要源于参与性参与游戏（互动），而不是生动和动态的感官刺激的影响。
This study sought to determine whether playing a “serious” interactive digital game (IDG) – the Re-Mission videogame for cancer patients – activates mesolimbic neural circuits associated with incentive motivation, and if so, whether such effects stem from the participatory aspects of interactive gameplay, or from the complex sensory/perceptual engagement generated by its dynamic event-stream. Healthy undergraduates were randomized to groups in which they were scanned with functional magnetic resonance imaging (FMRI) as they either actively played Re-Mission or as they passively observed a gameplay audio-visual stream generated by a yoked active group subject. Onset of interactive game play robustly activated mesolimbic projection regions including the caudate nucleus and nucleus accumbens, as well as a subregion of the parahippocampal gyrus. During interactive gameplay, subjects showed extended activation of the thalamus, anterior insula, putamen, and motor-related regions, accompanied by decreased activation in parietal and medial prefrontal cortex. Offset of interactive gameplay activated the anterior insula and anterior cingulate. Between-group comparisons of within-subject contrasts confirmed that mesolimbic activation was significantly more pronounced in the active playgroup than in the passive exposure control group. Individual difference analyses also found the magnitude of parahippocampal activation following gameplay onset to correlate with positive attitudes toward chemotherapy assessed both at the end of the scanning session and at an unannounced one-month follow-up. These findings suggest that IDG-induced activation of reward-related mesolimbic neural circuits stems primarily from participatory engagement in gameplay (interactivity), rather than from the effects of vivid and dynamic sensory stimulation.
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影响因子：
5.7
作者：
Cohen, MS
通讯作者：
Cohen, MS
影响因子：
4.8
作者：
Knutson, B;Cooper, JC
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Cooper, JC
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Grasby, PM
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作者：
Hoeft, Furniko;Watson, Christa L.;Reiss, Allan L.
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Reiss, Allan L.