Human hippocampal pre-activation predicts behavior.

Human hippocampal pre-activation predicts behavior.
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DOI:
10.1038/s41598-017-06477-5
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发表时间:
2017-07-20
期刊:
影响因子:
4.6
通讯作者:
Knight RT
Knight RT
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Jafarpour A;Piai V;Lin JJ;Knight RT

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对即将到来的突出事件的反应会加速,如果该事件在之前的事件中是预期的,即时间上下文效应。例如,根据强约束时间上下文命名图片比根据弱约束时间上下文命名图片要快。我们在没有事先训练的情况下,使用句子作为自然刺激来操纵对即将到来的图片的期望。在这里,使用来自人类海马体的颅内记录,我们发现在高期望图像之前的高频波段比弱期望图像更强。我们应用模式相似性分析对海马高频带活动的时间模式在单一海马接触。我们发现,在预测图像命名潜伏期的高频频带中,图像前间隔和预期图像间隔的海马电位模式具有更大的相似性。另外的模式相似性分析表明海马表征遵循语义图。结果表明,海马体对预期刺激的预激活是强大的情境行为效应的促进机制。
The response to an upcoming salient event is accelerated when the event is expected given the preceding events – i.e. a temporal context effect. For example, naming a picture following a strongly constraining temporal context is faster than naming a picture after a weakly constraining temporal context. We used sentences as naturalistic stimuli to manipulate expectations on upcoming pictures without prior training. Here, using intracranial recordings from the human hippocampus we found more power in the high-frequency band prior to high-expected pictures than weakly expected ones. We applied pattern similarity analysis on the temporal pattern of hippocampal high-frequency band activity in single hippocampal contacts. We found that greater similarity in the pattern of hippocampal field potentials between pre-picture interval and expected picture interval in the high-frequency band predicted picture-naming latencies. Additional pattern similarity analysis indicated that the hippocampal representations follow a semantic map. The results suggest that hippocampal pre-activation of expected stimuli is a facilitating mechanism underlying the powerful contextual behavioral effect.
DOI: 10.1523/jneurosci.2041-09.2009
发表时间: 2009-10-28
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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作者:
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发表时间: 2015-07-02
影响因子: 16.6
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发表时间: 2015-06-26
期刊: eLife
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发表时间: 2002-06-01
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