Lipopolysaccharide does not alter behavioral response to successive negative contrast in mice.
Lipopolysaccharide does not alter behavioral response to successive negative contrast in mice.
复制标题
脂多糖不会改变小鼠对连续阴性对照的行为反应。
DOI：
10.1007/s00213-020-05721-7
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发表时间：
2021-03
影响因子：
3.4
通讯作者：
Dantzer R
中科院分区：
文献类型：
--
作者：
Casaril AM;Vichaya EG;Rishi MR;Ford BG;Dantzer R
动机降低是炎症性抑郁症的主要症状之一。然而，炎症引起的动机改变的确切性质仍有待完全确定。由于炎症已被证明会增加对负刺激的敏感性，本系列实验旨在确定由低剂量脂多糖（LPS）诱导的全身炎症是否会影响小鼠对连续负对比的最终反应和仪器反应。连续负对比在操作上被定义为向较低价值奖励的转移，而不是接受训练的小鼠。老鼠被训练去喝高蔗糖浓度的溶液，当它们突然转向低浓度的溶液时，它们的反应是减少摄入的蔗糖量，减少舔食的次数和持续时间。在转移前24小时给予LPS并没有改变这些效应。以同样的方式，老鼠按照固定的强化计划（10次鼻子戳食物强化）被训练成用鼻子戳巧克力颗粒，然后转移到较低的奖励值（减少巧克力颗粒的数量或用不太喜欢的谷物颗粒代替巧克力颗粒），在24小时前给予LPS的影响下，以一种不一致的方式改变了它们的仪器反应。这些结果表明，LPS对连续负对比的影响具有高度可变性，并且未能提供证据支持LPS增加对预期奖励减少的敏感性的假设。
Reduced motivation is one of the main symptomatic features of inflammation-induced depression. However, the exact nature of inflammation-induced alterations in motivation remains to be fully defined. As inflammation has been shown to increase sensitivity to negative stimuli, the present series of experiments was initiated to determine whether systemic inflammation induced by infra-septic doses of lipopolysaccharide (LPS) in mice influences consummatory and instrumental responding to successive negative contrast. Successive negative contrast is operationally defined by a shift to a lower value reward than mice were trained with. Mice trained to drink a high sucrose concentration solution responded to an acute shift to a lower concentration of sucrose by a reduction in the volume of sucrose consumed and a decrease in lick numbers and bout durations. LPS administered 24 h before the shift did not modify these effects. In the same manner, mice trained to nose poke for chocolate pellets according to a fixed reinforcement schedule 10 (10 nose pokes for the food reinforcement) and shifted to a lower reward value (decreased number of chocolate pellets or replacement of chocolate pellets by less preferred grain pellets) altered their instrumental responding in a manner that did not vary consistently under the effect of LPS administered 24 h before. These results indicate a high variability in the effects of LPS on successive negative contrast and fails to provide evidence in favor of the hypothesis that LPS increases sensitivity to decreases in expected rewards.
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影响因子：
8.2
作者：
Dooley LN;Kuhlman KR;Robles TF;Eisenberger NI;Craske MG;Bower JE
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影响因子：
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作者：
Harrison NA;Voon V;Cercignani M;Cooper EA;Pessiglione M;Critchley HD
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影响因子：
4.6
作者：
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通讯作者：
Nuydens R
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Dantzer, R