HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia.
HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia.
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DOI：
10.3389/fimmu.2014.00652
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发表时间：
2014
影响因子：
7.3
通讯作者：
Hviid TV
中科院分区：
文献类型：
--
作者：
Djurisic S;Hviid TV
尽管经过几十年的研究，高度流行的妊娠并发症先兆子痫，“理论疾病”，仍然是一个谜。事实上，先兆子痫的病因在很大程度上是未知的。大量的研究表明，病理基础涉及一系列复杂的遗传易感性和免疫适应不良，母亲、父亲和胎儿的贡献可能很重要。人类白细胞抗原（HLA）-G是一个越来越多的研究与先兆子痫的焦点。HLA-G分子主要由衬在胎盘上的绒毛外滋养层细胞与另外两种HLA Ib类分子HLA-E和HLA-F一起表达。在早期子宫内膜、成熟的卵丘-卵母细胞复合体、孕妇的母血、脐带血和最近的精浆中检测到HLA-G的可溶性亚型。HLA-G被认为参与调节妊娠期间血管重塑背景下的免疫应答以及抑制针对半同种异体胎儿的潜在有害免疫攻击。此外，HLA-G遗传变异与HLA-G的膜结合形式和可溶性形式两者相关，并且在一些研究中与先兆子痫相关。在这篇综述中，遗传贡献的母亲，父亲和胎儿，以及存在和功能的各种免疫细胞的相关性在怀孕期间审查HLA-G和先兆子痫。
Despite decades of research, the highly prevalent pregnancy complication preeclampsia, “the disease of theories,” has remained an enigma. Indeed, the etiology of preeclampsia is largely unknown. A compiling amount of studies indicates that the pathological basis involves a complex array of genetic predisposition and immunological maladaptation, and that a contribution from the mother, the father, and the fetus is likely to be important. The Human Leukocyte Antigen (HLA)-G is an increasing focus of research in relation to preeclampsia. The HLA-G molecule is primarily expressed by the extravillous trophoblast cells lining the placenta together with the two other HLA class Ib molecules, HLA-E and HLA-F. Soluble isoforms of HLA-G have been detected in the early endometrium, the matured cumulus–oocyte complex, maternal blood of pregnant women, in umbilical cord blood, and lately, in seminal plasma. HLA-G is believed to be involved in modulating immune responses in the context of vascular remodeling during pregnancy as well as in dampening potential harmful immune attacks raised against the semi-allogeneic fetus. In addition, HLA-G genetic variants are associated with both membrane-bound and soluble forms of HLA-G, and, in some studies, with preeclampsia. In this review, a genetic contribution from the mother, the father, and the fetus, together with the presence and function of various immune cells of relevance in pregnancy are reviewed in relation to HLA-G and preeclampsia.
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影响因子：
10.7
作者：
Castelli, Erick C.;Mendes-Junior, Celso T.;Donadi, Eduardo A.
通讯作者：
Donadi, Eduardo A.
影响因子：
3.4
作者：
Aldrich, C;Verp, MS;Ober, C
通讯作者：
Ober, C
NK 细胞溶解取决于 HLA-G 表达的比例。
影响因子：
2.7
作者：
Chen, Bao-Guo;Xu, Dan-Ping;Yan, Wei-Hua
通讯作者：
Yan, Wei-Hua
DOI：
10.1111/j.1600-0897.2006.00429.x
发表时间：
2006-11-01
影响因子：
3.6
作者：
Bachmayer, Nora;Hamad, Rangeen Rafik;Sverremark-Ekstrom, Eva
通讯作者：
Sverremark-Ekstrom, Eva
DOI：
10.3324/haematol.2010.025825
发表时间：
2010-12-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Bacchetta, Rosa;Gregori, Silvia;Roncarolo, Maria Grazia
通讯作者：
Roncarolo, Maria Grazia