Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex.
Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex.
复制标题
DOI：
10.1038/s41467-022-34261-1
复制
发表时间：
2022-11-03
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
啮齿动物的感觉皮层包含了感觉特征的盐和胡椒地图，其结构还不完全清楚。在这里，我们研究了盐和胡椒晶须的躯体感觉皮层L2/3锥体神经元的结构，清醒的小鼠进行一个与所有的晶须歧视。柱状（CW）和非柱状（non-CW）晶须调谐的神经元在空间上混合，共同调谐的神经元形成局部（20 µm）簇。在专家小鼠中，触须调谐明显不稳定，35-46%的锥体细胞在5-18天内显著改变调谐。调谐不稳定性高度集中在非CW调谐的神经元中，因此在图中是结构化的。非CW神经元的不稳定性是不变的慢性胡须麻痹，当小鼠区分个别胡须，这表明它是一个固有的功能。因此，L2/3结合了两个不同的组成部分：CW调谐细胞的稳定柱状框架，可以促进空间感知的稳定性，加上混合的，非柱状的周围高度不稳定的调谐。啮齿类动物的感觉皮层包含了各种感觉特征的混合表征。在这里，作者研究了清醒小鼠执行感觉辨别任务的L2/3锥体神经元之间的触须躯体位置图。
Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not fully known. Here we investigated the structure of the salt-and-pepper whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex, in awake mice performing one-vs-all whisker discrimination. Neurons tuned for columnar (CW) and non-columnar (non-CW) whiskers were spatially intermixed, with co-tuned neurons forming local (20 µm) clusters. Whisker tuning was markedly unstable in expert mice, with 35-46% of pyramidal cells significantly shifting tuning over 5-18 days. Tuning instability was highly concentrated in non-CW tuned neurons, and thus was structured in the map. Instability of non-CW neurons was unchanged during chronic whisker paralysis and when mice discriminated individual whiskers, suggesting it is an inherent feature. Thus, L2/3 combines two distinct components: a stable columnar framework of CW-tuned cells that may promote spatial perceptual stability, plus an intermixed, non-columnar surround with highly unstable tuning. Rodent sensory cortex contains intermixed representations of sensory features. Here the authors investigated the whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex in awake mice performing a sensory discrimination task.
登录
查看更多内容
影响因子：
16.6
作者：
Kondo, Satoru;Yoshida, Takashi;Ohki, Kenichi
通讯作者：
Ohki, Kenichi
影响因子：
16.6
作者：
Estebanez, Luc;Bertherat, Julien;Shulz, Daniel E.;Bourdieu, Laurent;Leger, Jean-Francois
通讯作者：
Leger, Jean-Francois
影响因子：
7.7
作者：
Barchini J;Shi X;Chen H;Cang J
通讯作者：
Cang J
影响因子：
5.3
作者：
Andermann ML;Kerlin AM;Reid RC
通讯作者：
Reid RC
影响因子：
25
作者：
Chan KY;Jang MJ;Yoo BB;Greenbaum A;Ravi N;Wu WL;Sánchez-Guardado L;Lois C;Mazmanian SK;Deverman BE;Gradinaru V
通讯作者：
Gradinaru V