Impulsivity in children and adolescents with mood disorders and unaffected offspring of bipolar parents.
Impulsivity in children and adolescents with mood disorders and unaffected offspring of bipolar parents.
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患有情绪障碍的儿童和青少年以及双相情感障碍父母未受影响的后代的冲动。
DOI：
10.1016/j.comppsych.2014.04.018
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发表时间：
2014
影响因子：
7.3
通讯作者：
Soares,JairC
中科院分区：
文献类型：
--
作者：
Sanches,Marsal;Scott-Gurnell,Kathy;Patel,Anita;Caetano,SheilaC;Zunta-Soares,GiovanaB;Hatch,JohnP;Olvera,Rene;Swann,AlanC;Soares,JairC
冲动性增加似乎存在于双相情感障碍（BD）的所有阶段。因此，冲动可能代表BD的内在表型，如果它也存在于情绪障碍遗传风险高的正常个体中。在这项研究中，我们评估了四组不同儿童和青少年的冲动性：BD患者、重度抑郁症（MDD）患者、双相父母（UO）的未受影响的后代和健康对照（HC）。对象和方法52名BD患者、31名MDD患者、20名UO和45名HC完成Barratt冲动量表（BIS-11），结果UO患者的BIS-11冲动性总分显著高于HC患者（P = 0. 02），但低于BD患者（F = 27. 12，P <0. 01）。多重比较分析显示BD患者的BIS-11总分高于HC（p < 0.01）和UO（p < 0.01）。MDD患者的BIS-11评分高于HC患者（p < 0.01）。MDD患者和UO之间的差异，以及MDD和BD patients之间的差异，没有统计学意义。ConclusionOur findings suggest that trait impulsivity is increased among children and adolescents with mood disorders，as well as in unaffected individuals at high genetic risk for BD.
ObjectiveIncreased impulsivity seems to be present across all phases of bipolar disorder (BD). Impulsivity may therefore represent an endophenotype for BD, if it is also found among normal individuals at high genetic risk for mood disorders. In this study, we assessed impulsivity across four different groups of children and adolescents: patients with BD, major depressive disorder (MDD) patients, unaffected offspring of bipolar parents (UO), and healthy controls (HC).Subjects and Methods52 patients with BD, 31 with MDD, 20 UO, and 45 HC completed the Barratt Impulsiveness Scale (BIS-11), an instrument designed to measure trait impulsivity.ResultsUO displayed significantly higher total BIS-11 impulsivity scores than HC (p = 0.02) but lower scores than BD patients (F = 27.12, p < 0.01). Multiple comparison analysis revealed higher BIS-11 total scores among BD patients when compared to HC (p < 0.01) and UO (p < 0.01). MDD patients had higher BIS-11 scores when compared to HC (p < 0.01). Differences between MDD patients and UO, as well as between MDD and BD patients, were not statistically significant.ConclusionOur findings suggest that trait impulsivity is increased among children and adolescents with mood disorders, as well as in unaffected individuals at high genetic risk for BD.
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影响因子：
10.6
作者：
P. Quintin;C. Benkelfat;J. Launay;I. Arnulf;Agnes Pointereau;S. Barbault;J. Alvarez;O. Varoquaux;F. Pérez;R. Jouvent;M. Leboyer
通讯作者：
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DOI：
10.1097/00004583-199707000-00021
发表时间：
1997-07-01
影响因子：
13.3
作者：
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通讯作者：
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影响因子：
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作者：
Peluso, M. A. M.;Hatch, J. P.;Soares, J. C.
通讯作者：
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影响因子：
6.6
作者：
Swann, AC;Pazzaglia, P;Moeller, FG
通讯作者：
Moeller, FG