Interferon-gamma promotes abortion due to Brucella infection in pregnant mice.
Interferon-gamma promotes abortion due to Brucella infection in pregnant mice.
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DOI：
10.1186/1471-2180-5-22
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发表时间：
2005-05-04
期刊：
影响因子：
4.2
通讯作者：
Watarai M
中科院分区：
文献类型：
--
作者：
Kim S;Lee DS;Watanabe K;Furuoka H;Suzuki H;Watarai M
细菌感染引起流产的机制在很大程度上是未知的。在本研究中，我们研究了流产布鲁氏菌，布鲁氏菌病的病原体和兼性细胞内病原体，在小鼠模型中引起的流产。在妊娠第4.5天观察到细菌感染的流产率很高，但在其他日子则没有。无论胎儿是否流产或存活，均观察到细菌进入胎儿的传播和胎盘中的细菌复制。胎盘中细菌定植程度高于其他器官，在胎盘滋养层巨细胞中检测到许多细菌。细胞内生长缺陷型virB 4突变体和减毒疫苗株S19不诱导流产。在流产的情况下，在妊娠第7.5天左右（胎盘发育期），观察到野生型菌株感染对IFN-γ产生的瞬时诱导，但未观察到virB 4突变体和S19感染。IFN-γ的中和，其产生由B感染诱导。堕胎，用来防止堕胎。这些结果表明，B.流产感染是胎盘发育期间瞬时产生IFN-γ的结果。
The mechanisms of abortion induced by bacterial infection are largely unknown. In the present study, we investigated abortion induced by Brucella abortus, a causative agent of brucellosis and facultative intracellular pathogen, in a mouse model. High rates of abortion were observed for bacterial infection on day 4.5 of gestation, but not for other days. Regardless of whether fetuses were aborted or stayed alive, the transmission of bacteria into the fetus and bacterial replication in the placenta were observed. There was a higher degree of bacterial colonization in the placenta than in other organs and many bacteria were detected in trophoblast giant cells in the placenta. Intracellular growth-defective virB4 mutant and attenuated vaccine strain S19 did not induce abortion. In the case of abortion, around day 7.5 of gestation (period of placental development), transient induction of IFN-γ production was observed for infection by the wild type strain, but not by the virB4 mutant and S19. Neutralization of IFN-γ, whose production was induced by infection with B. abortus, served to prevent abortion. These results indicate that abortion induced by B. abortus infection is a result of transient IFN-γ production during the period of placental development.
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