Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis.
Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis.
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CTLA-4基因多态性与类风湿性关节炎风险之间的关联：荟萃分析
DOI：
10.18632/aging.203349
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发表时间：
2021-08-02
期刊：
影响因子：
--
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Zhou C;Gao S;Yuan X;Shu Z;Li S;Sun X;Xiao J;Liu H
细胞毒性T淋巴细胞相关蛋白4 （CTLA-4）基因多态性可能参与类风湿关节炎（RA）的风险。然而，这种关联的证据仍然存在争议。因此，我们进行了荟萃分析，以确认CTLA-4基因多态性与RA之间的关系。计算合并优势比（or）和95%置信区间（ci）来评估关联强度。按种族进行分层分析。共获得66项病例对照研究，其中病例21681例，对照23457例。rs3087243多态性在亚洲人（A vs. G: OR=0.77, 95%CI=0.65 ~ 0.90， P=0.001; AA vs. GG: OR=0.67, 95%CI=0.48 ~ 0.94， P=0.02）和高加索人（A vs. G: OR=0.89, 95%CI=0.86 ~ 0.93， P<0.00001; AA vs. GG: OR=0.81, 95%CI=0.75 ~ 0.88， P<0.00001）中检测到显著关联。rs231775多态性在总体（G vs. A: OR= 1.16, 95%CI=1.08-1.25， P<0.0001; GG vs. AA: OR=1.29, 95%CI=1.12-1.50， P=0.0006）和亚洲人（G vs. A: OR=1.27, 95%CI=1.10-1.47， P=0.001; GG vs. AA: OR=1.58, 95%CI=1.24-2.01， P=0.0002）中观察到显著相关性，但在白种人中无显著相关性。然而，rs5742909多态性与RA之间没有关联。该荟萃分析证实rs3087243和rs231775多态性在总体人群和种族特异性分析中与RA风险相关，但rss5742909多态性与RA风险无关。
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association. Stratified analysis was conducted by ethnicity. In total, 66 case-control studies including 21681 cases and 23457 controls were obtained. For rs3087243 polymorphism, significant association was detected in Asians (A vs. G: OR=0.77, 95%CI=0.65-0.90, P=0.001; AA vs. GG: OR=0.67, 95%CI=0.48-0.94, P=0.02) and Caucasians (A vs. G: OR=0.89, 95%CI=0.86-0.93, P<0.00001; AA vs. GG: OR=0.81, 95%CI=0.75-0.88, P<0.00001). For rs231775 polymorphism, significant association was observed in the overall (G vs. A: OR =1.16, 95%CI=1.08-1.25, P<0.0001; GG vs. AA: OR=1.29, 95%CI=1.12-1.50, P=0.0006), and in Asians (G vs. A: OR=1.27, 95%CI=1.10-1.47, P=0.001; GG vs. AA: OR=1.58, 95%CI=1.24-2.01, P=0.0002), but not in Caucasians. However, there was no association between rs5742909 polymorphism and RA. This meta-analysis confirmed that rs3087243 and rs231775 polymorphism were associated with the risk of RA in both overall population and ethnic-specific analysis, but there was no association between rs5742909 polymorphism and RA risk.
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影响因子：
3.5
作者：
Elshazli, Rami;Settin, Ahmad;Salama, Afrah
通讯作者：
Salama, Afrah
影响因子：
3.5
作者：
Barton A;Eyre S;Ke X;Hinks A;Bowes J;Flynn E;Martin P;YEAR Consortium;BIRAC Consortium;Wilson AG;Morgan AW;Emery P;Steer S;Hocking LJ;Reid DM;Harrison P;Wordsworth P;Thomson W;Worthington J
通讯作者：
Worthington J
影响因子：
4.9
作者：
Costenbader KH;Chang SC;De Vivo I;Plenge R;Karlson EW
通讯作者：
Karlson EW
DOI：
10.1073/pnas.1603892113
发表时间：
2016-04-26
影响因子：
11.1
作者：
Klocke, Katrin;Sakaguchi, Shimon;Wing, Kajsa
通讯作者：
Wing, Kajsa
影响因子：
5.5
作者：
Kacem, HH;Kaddour, N;Ayadi, H
通讯作者：
Ayadi, H