Breast cancer incidence in the regions of Belarus and Ukraine most contaminated by the Chernobyl accident: 1978 to 2016.
Breast cancer incidence in the regions of Belarus and Ukraine most contaminated by the Chernobyl accident: 1978 to 2016.
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受切尔诺贝利事故污染最严重的白俄罗斯和乌克兰地区的乳腺癌发病率：1978年至2016年。
DOI：
10.1002/ijc.33346
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发表时间：
2021-04-15
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
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作者：
即使在事故发生30年后，乳腺癌发病率与切尔诺贝利放射性尘埃的电离辐射暴露之间的联系仍然不确定。我们研究了白俄罗斯（戈梅利和莫吉廖夫）和乌克兰（基辅，日托米尔和切尔尼希夫）污染最严重地区在事故发生前（1978 - 1986）和事故发生后（1987 - 2016）的乳腺癌发病率。乳腺癌病例和女性人口规模数据来自国家癌症登记处和国家统计部门。该研究包括85132例乳腺癌，风险为1.5亿人年。我们估计了1986 - 2016年期间成年女性人口的外部和内部照射的年度人造丝（地区）平均吸收剂量。我们研究了射线平均累积吸收乳腺剂量与5年的滞后，也就是说，排除暴露在5年前的乳腺癌诊断，乳腺癌发病率之间的关联使用负二项回归模型。2016年白俄罗斯的平均（中位数）累积乳腺剂量为12.3（5.0）毫戈瑞（mGy），乌克兰为5.7（2.3）mGy，最大剂量分别为55 mGy和54 mGy。乳腺癌发病率随着历年和年龄的增长而显著增加，城市居民高于农村居民。调整时间，年龄和城市化的影响，我们发现没有证据表明发病率增加与射线平均5年滞后累积乳房剂量。由于生态研究设计的局限性，需要进行一项病例对照研究，对切尔诺贝利事故后低剂量长期辐射照射与乳腺癌风险之间的关系进行检验，该研究涵盖了这一地区，并对乳腺吸收剂量进行了单独重建。
Even 30 years after the accident, an association between breast cancer incidence and ionizing radiation exposure from Chernobyl fallout remains uncertain. We studied breast cancer incidence in the most contaminated regions of Belarus (Gomel and Mogilev) and Ukraine (Kyiv, Zhytomyr and Chernihiv) before (1978–1986) and after (1987–2016) the accident. Breast cancer cases and female population size data were received from the national cancer registries and the state departments of statistics. The study included 85 132 breast cancers with 150 million person-years at risk. We estimated annual rayon (district)-average absorbed doses to the breast from external and internal irradiation of the adult female population over the period of 1986–2016. We studied an association between rayon-average cumulative absorbed breast dose with 5-year lag, that is, excluding the exposure in 5 years prior to breast cancer diagnosis, and breast cancer incidence using negative binomial regression models. Mean (median) cumulative breast dose in 2016 was 12.3 (5.0) milligray (mGy) in Belarus and 5.7 (2.3) mGy in Ukraine, with the maximum dose of 55 mGy and 54 mGy, respectively. Breast cancer incidence rates statistically significantly increased with calendar year and attained age, and were higher in urban than in rural residents. Adjusting for time, age and urbanicity effects, we found no evidence of increasing incidence with rayon-average 5-year lagged cumulative breast dose. Owing to ecological study design limitations, a case-control study covering this area with individually reconstructed absorbed breast doses is needed testing for association between low-dose protracted radiation exposure and breast cancer risk after Chernobyl.
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DOI：
10.1016/j.ijrobp.2012.09.001
发表时间：
2013-06-01
影响因子：
7
作者：
de Gonzalez, Amy Berrington;Gilbert, Ethel;Curtis, Rochelle;Inskip, Peter;Kleinerman, Ruth;Morton, Lindsay;Rajaraman, Preetha;Little, Mark P.
通讯作者：
Little, Mark P.
影响因子：
2.2
作者：
Bouville, Andre;Likhtarev, Illya A.;Drozdovitch, Vladimir V.
通讯作者：
Drozdovitch, Vladimir V.
DOI：
10.33145/2304-8336-2018-23-164-187
发表时间：
2018-12-01
影响因子：
--
作者：
Ivanova, O M;Kovgan, L M;Masiuk, S V
通讯作者：
Masiuk, S V
影响因子：
0.5
作者：
Khrushchinskii, A. A.;Kuten', S. A.;Drozdovitch, V. V.
通讯作者：
Drozdovitch, V. V.
1983-2008 年美国放射技术专家队列中乳腺癌风险和长期低至中等剂量职业辐射暴露。
影响因子：
8.8
作者：
Preston, D. L.;Kitahara, C. M.;Freedman, D. M.;Sigurdson, A. J.;Simon, S. L.;Little, M. P.;Cahoon, E. K.;Rajaraman, P.;Miller, J. S.;Alexander, B. H.;Doody, M. M.;Linet, M. S.
通讯作者：
Linet, M. S.