Breast cancer risk and protracted low-to-moderate dose occupational radiation exposure in the US Radiologic Technologists Cohort, 1983-2008.
Breast cancer risk and protracted low-to-moderate dose occupational radiation exposure in the US Radiologic Technologists Cohort, 1983-2008.
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1983-2008 年美国放射技术专家队列中乳腺癌风险和长期低至中等剂量职业辐射暴露。
DOI：
10.1038/bjc.2016.292
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发表时间：
2016-10-25
影响因子：
8.8
通讯作者：
Linet, M. S.
中科院分区：
文献类型：
--
作者：
Preston, D. L.;Kitahara, C. M.;Freedman, D. M.;Sigurdson, A. J.;Simon, S. L.;Little, M. P.;Cahoon, E. K.;Rajaraman, P.;Miller, J. S.;Alexander, B. H.;Doody, M. M.;Linet, M. S.
虽然高剂量电离辐射与乳腺癌风险增加有关，但与长期低剂量率暴露的关系仍不清楚。美国放射技术人员的研究提供了一个机会，以检查低至中等剂量辐射和乳腺癌发病率和死亡率之间的关系。在1983-2005年期间，66915名女性技术人员中诊断出1922例自我报告的第一原发性癌症，1983-2008年期间，83538名女性队列成员中发生了586例乳腺癌死亡。职业乳房剂量估计是根据工作历史，历史数据，并在20世纪70年代中期，个人电影徽章测量。使用Poisson回归，出生队列分层，调整绝经，生育史和其他危险因素，估计超额相对风险。较高剂量与乳腺癌发病率增加相关，100 mGy时的超额相对风险为0.07（95%置信区间（CI）：-0.005至0.19）。1930年以前出生的技术人员的相关性最强（100 mGy时的超额相对风险=0.16; 95% CI：0.03-0.39），1930年以前出生的技术人员的死亡率模式相似。职业性乳腺辐射与乳腺癌风险呈正相关。1930年以前出生、1950年以前开始工作的妇女的危险更大，因为1950年以前的平均年剂量（37毫戈瑞）大大高于后来的年剂量（1.3毫戈瑞）。然而，由于1960年以前的职业剂量估计存在不确定性和可能的系统误差，因此应谨慎对待这些结果。
Although high-dose ionising radiation is associated with increased breast cancer risks, the association with protracted low-dose-rate exposures remains unclear. The US Radiologic Technologist study provides an opportunity to examine the association between low-to-moderate dose radiation and breast cancer incidence and mortality. One thousand nine hundred and twenty-two self-reported first primary cancers were diagnosed during 1983–2005 among 66 915 female technologists, and 586 breast cancer deaths occurred during 1983–2008 among 83 538 female cohort members. Occupational breast dose estimates were based on work histories, historical data, and, after the mid-1970s, individual film badge measurements. Excess relative risks were estimated using Poisson regression with birth cohort stratification and adjustment for menopause, reproductive history, and other risk factors. Higher doses were associated with increased breast cancer incidence, with an excess relative risk at 100 mGy of 0.07 (95% confidence interval (CI): -0.005 to 0.19). Associations were strongest for technologists born before 1930 (excess relative risk at 100 mGy=0.16; 95% CI: 0.03–0.39) with similar patterns for mortality among technologists born before 1930. Occupational radiation to the breast was positively associated with breast cancer risk. The risk was more pronounced for women born before 1930 who began working before 1950 when mean annual doses (37 mGy) were considerably higher than in later years (1.3 mGy). However, because of the uncertainties and possible systematic errors in the occupational dose estimates before 1960, these findings should be treated with caution.
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影响因子：
1.9
作者：
Langholz B;Thomas DC;Stovall M;Smith SA;Boice JD Jr;Shore RE;Bernstein L;Lynch CF;Zhang X;Bernstein JL
通讯作者：
Bernstein JL
影响因子：
3.8
作者：
Ronckers, Cecile M.;Doody, Michele M.;Land, Charles E.
通讯作者：
Land, Charles E.
DOI：
10.1093/jnci/87.22.1681
发表时间：
1995-11-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
MADIGAN, MP;ZIEGLER, RG;HOOVER, RN
通讯作者：
HOOVER, RN
影响因子：
6.2
作者：
Sigurdson, AJ;Doody, MM;Linet, MS
通讯作者：
Linet, MS
影响因子：
3.4
作者：
Eidemueller, M.;Ostroumova, E.;Jacob, P.
通讯作者：
Jacob, P.